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Extraction and separation method of multiple components of ganoderma lucidum and application of extraction and separation method in preparation of artificially planted ganoderma lucidum extract

A separation method and multi-component technology, which can be applied to medical preparations containing active ingredients, plant raw materials, pharmaceutical formulations, etc., can solve the problems of low extraction efficiency, inability to prepare high-quality artificial Ganoderma lucidum products, and low extraction purity of Ganoderma lucidum polysaccharides. , to achieve the effect of improving extraction purity, improving biological safety and reducing production costs

Active Publication Date: 2022-04-22
贵州中科分子生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defects and deficiencies of low extraction efficiency of ganoderma polysaccharides and other components in the deep processing of ganoderma lucidum, low extraction purity of ganoderma polysaccharides, and inability to prepare high-quality artificial ganoderma products, and provide a multi-component extraction and separation of ganoderma lucidum method

Method used

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  • Extraction and separation method of multiple components of ganoderma lucidum and application of extraction and separation method in preparation of artificially planted ganoderma lucidum extract
  • Extraction and separation method of multiple components of ganoderma lucidum and application of extraction and separation method in preparation of artificially planted ganoderma lucidum extract

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A method for extracting and separating ganoderma multi-components, comprising the steps of:

[0050] The ganoderma lucidum is crushed and then extracted, and the extract is separated in multiple stages to obtain a ganoderma polysaccharide enrichment and a ganoderma triterpene enrichment.

[0051] The specific operation is as follows:

[0052] 1. Crushing (crushing): crush 5Kg of Ganoderma lucidum, and then crush it until it can pass through a 30-mesh sieve;

[0053]2. Feeding: Take 5Kg of mixed raw materials as a batch of feeding, put it into the feeding tank, add 100L hot water according to the ratio of material to water of 1:20, make the temperature of the material liquid at 60°C, and stir evenly;

[0054] 3. Extraction: transport the feed liquid to the extraction and breaking unit for extraction, and the extraction cycle time is 18 minutes;

[0055] 4. Centrifugation: centrifuge the material extract, the frequency of the main centrifuge is 42.0Hz, the frequency of ...

Embodiment 2

[0061] A preparation method of artificial Ganoderma lucidum combined with instant Ganoderma lucidum essence:

[0062] Wild Ganoderma lucidum was extracted according to the extraction and separation method of multi-components of Ganoderma lucidum in the above-mentioned embodiment 1, and multi-stage separation was carried out to obtain Ganoderma lucidum polysaccharide enrichment and Ganoderma triterpene enrichment;

[0063] Extract the artificial Ganoderma lucidum according to the method for extracting and separating the multi-components of Ganoderma lucidum in the above-mentioned embodiment 1, and obtain the Ganoderma lucidum polysaccharide enrichment and Ganoderma triterpene enrichment through multi-stage separation;

[0064] The Ganoderma lucidum polysaccharide enrichment and the Ganoderma triterpene enrichment of the artificial Ganoderma lucidum are blended according to the mass ratio of the Ganoderma lucidum polysaccharide enrichment and the Ganoderma triterpene enrichment i...

Embodiment 3

[0066] A method for extracting and separating ganoderma multi-components, comprising the steps of:

[0067] The Ganoderma lucidum is crushed and then extracted, and the extract is separated in multiple stages to obtain Ganoderma lucidum polysaccharide enrichment and Ganoderma triterpene enrichment.

[0068] The specific operation is as follows:

[0069] 1. Crushing (crushing): crush 5Kg of Ganoderma lucidum, and then crush it until it can pass through a 30-mesh sieve.

[0070] 2. Feeding: Take 5Kg of mixed raw materials as a batch of feeding, put it into the feeding tank, add 100L hot water according to the ratio of material to water of 1:20, keep the temperature of the material liquid at 80°C, and stir evenly.

[0071] 3. Extraction: The material liquid is transported to the extraction and breaking unit for extraction, and the extraction cycle time is 20 minutes.

[0072] 4. Centrifugation: Centrifuge the material extract, the frequency of the main centrifuge is 42.0Hz, the...

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Abstract

The invention discloses a ganoderma lucidum multi-component extraction and separation method and application thereof in preparation of an artificially planted ganoderma lucidum extract, and belongs to the technical field of deep processing of ganoderma lucidum. The ganoderma lucidum multi-component extraction and separation method comprises the following steps that ganoderma lucidum is crushed and then extracted, multi-stage separation is conducted on an extract, a ganoderma lucidum polysaccharide enrichment and a ganoderma lucidum triterpene enrichment are obtained, the material-liquid ratio of extraction is 1: (18-22), the extraction temperature is 60-80 DEG C, and the extraction time is 1-2 h; the multi-stage separation comprises the following steps: separating the extract by adopting a nanofiltration membrane with the molecular weight of 1000 to obtain ganoderma lucidum polysaccharide, and separating by adopting a nanofiltration membrane with the molecular weight of 500 to obtain ganoderma lucidum triterpenes. According to the preparation method, the purity of the beneficial components is effectively improved, the purity of the ganoderma lucidum polysaccharide can reach about 10%, the production cost of a ganoderma lucidum product is reduced, heavy metal and pesticide residues are obviously reduced, and the product safety is good.

Description

technical field [0001] The invention relates to the technical field of ganoderma lucidum deep processing, and more specifically relates to a multi-component extraction and separation method of ganoderma lucidum and its application in the preparation of artificially planted ganoderma lucidum extract. Background technique [0002] Ganoderma lucidum, umbrella-shaped in shape, with a kidney-shaped, semicircular or nearly round cap, is the fruiting body of the polyporaceae fungus Ganoderma lucidum. According to chemical analysis, Ganoderma lucidum fruit and mycelia contain polysaccharides, various amino acids, organic germanium, steroids and triterpenoids. Pharmacological studies have shown that Ganoderma lucidum has the functions of protecting the liver, detoxifying, strengthening the heart, calming the nerves, relieving pain and treating tinnitus. , beneficial lung qi, sharp joints and other functions. The chemical characteristics of Ganoderma lucidum, especially the chemical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074
CPCA61K36/074A61K2236/331A61K2236/53A61K2236/51Y02P20/10
Inventor 周姗妮郑锐龙丁明浩
Owner 贵州中科分子生物有限公司
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