The invention provides a heat-resistant high-pressure casting Al-Si-Ni-Cu aluminum alloy and a preparation method thereof, the aluminum alloy comprises the following elements in percentage by weight:10.5-12.0% of Si, 2.0-5.0% of Ni, 2.0-4.0% of Cu, 0.05-0.2% of Mg, 0.1-0.5% of Cr, 0.01-0.04% of Sr, 0.3-0.6% of M, 0.1-0.5% of Fe and the balance of Al, wherein M is at least two elements of Ti, Zr,and V. The tensile strength of die-casting alloy at room temperature, 350 DEG C instantaneous and 350 thermal insulation is 318-360 MPa, 140-155 MPa and 75-93 MPa, and the elongation is 1.2-2.0%, 5.3-6.3% and 5.8-7.2%; without solution heat treatment, the die-casting alloy can be applied to automotive heat-resistant parts such as pistons so as to meet the needs of automotive lightweight development.