Tissue adhesive matrices and uses thereof

A tissue, matrix technology, applied in the field of tissue adhesion matrix and its use, can solve problems such as lack of adhesion strength

Pending Publication Date: 2022-04-26
NURAMI MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Hydrogels, on the other hand, are considered safe but...

Method used

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  • Tissue adhesive matrices and uses thereof
  • Tissue adhesive matrices and uses thereof
  • Tissue adhesive matrices and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0329] Preparation of Exemplary Compositions and Controls

[0330] Polymer blend fibers (exemplary compositions of the invention and controls) were prepared as follows:

[0331] The electrospinning process was performed at a temperature of 23±5°C and a relative humidity of 35±10% using a syringe pump, a 22-gauge needle (inner diameter ~0.51 mm) and a high voltage (maximum 30 kV) DC power supply. The solution flow rate was 2.6 ml / hr with a voltage supply of 6±2 kV and a tip-to-collector distance of 5-8 cm. The patches were collected on a rotating aluminum vertical wheel with a diameter of 51 mm and a width of 45 mm at 310 rpm. The patch was prepared with a thickness of 200 ± 30 μm and dried in vacuum at room temperature for 24 hours to remove residual solvent.

[0332] Preparation of PLCL fibers containing activated PEG polymer

[0333] Control 1.1: Electrospinning of blended PLCL to methoxy-PEG-NHS (Mw=20K) at a ratio of 1:0.333 (w / w) [6.67E-06, 1.65E-05 mol, respectively]....

Embodiment 2

[0366] Peel Test Procedure

[0367] Samples of each matrix layer of electrospun fibers were cut into 15 mm x 30 mm strips; half of the strips were wetted with saline, while the other half were left dry. Such as figure 1 As shown, each strip was placed in parallel on top of a wet 15 mm x 30 mm collagen strip to yield a minimum binding area of ​​15 x 15 mm. The wet half of each sample was pressed onto the collagen strip for 2 minutes, and then the other half was left unbound to the collagen to form the peel arm. For better handling, all samples were dried at room temperature. The force required to break the bond between the collagen and the sample was measured using a universal testing machine LLOYD LS1. Pull the peel arm apart at a speed of 10 mm / min and measure the force required to break the bond. Adhesive strength is defined by the average of the peel force and maximum force recorded during the test.

[0368] Shear Test Procedure

[0369] Such as figure 2 Wet collage...

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Abstract

Disclosed are compositions comprising a first polymer, a second branched polymer, and a third polymer reactive to the second polymer, where either of the second and third polymers comprises a tissue binding group, and where the second polymer and the third polymer are at least partially cross-linked. A matrix comprising the composition of the invention and optionally an additional polymer layer is disclosed. Methods for making the compositions and their use for bioadhesive and/or repair of damaged tissue are also disclosed.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 876,952, filed July 22, 2019, the contents of which are incorporated herein by reference in their entirety. technical field [0003] In some of its embodiments, the present invention relates to tissue adhesion matrices, their preparation and use. Background technique [0004] Leakage of fluid or air from or into damaged tissue is a potentially life-threatening condition that can occur due to a variety of conditions, including surgery and trauma. [0005] Soft tissues are particularly vulnerable to damage. In addition, these tissues sometimes form various fluid- or air-holding compartments (eg, lungs, blood vessels, dura mater, bladder, etc.), and when damaged, their damage extends to other areas as well. Additionally, due to the mechanical properties of these tissues, attaching the matrix with sutures or staples may cause damage to that ti...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61K9/70C08L71/02C08L81/02C08G75/26
CPCC08L71/02C08L81/02C08G75/23C08G65/33331C08G2650/50A61L24/0031A61L24/043A61L24/0036A61L24/0015A61L27/56A61L27/52A61L27/54A61L27/26C08G65/4056C08L67/00
Inventor N·尼希尔马纳沙A·巴哈尔R·奥马尔
Owner NURAMI MEDICAL LTD
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