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Application of verbascoside in preparation of medicine for treating androgenetic alopecia

A technology of acteoside and androgenic properties, applied in the field of application of acteoside in the preparation of drugs for treating androgenetic alopecia, achieving the effect of promoting hair growth, no adverse reactions, and convenient material collection

Pending Publication Date: 2022-05-20
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, up to now, no scholars have researched and developed verbascoside from the perspective of hair growth[10]

Method used

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  • Application of verbascoside in preparation of medicine for treating androgenetic alopecia
  • Application of verbascoside in preparation of medicine for treating androgenetic alopecia
  • Application of verbascoside in preparation of medicine for treating androgenetic alopecia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Actascoside promotes hair growth

[0029] Trial grouping and drug intervention:

[0030] Male C57BL / 6J mice were divided into 4 groups according to the random number table. Namely blank group (smear blank matrix; n=9), model group (smear blank matrix 0.2ml; n=11), acteoside-low dose group (smear 30mg / ml verbascoside 0.2ml; n=9), acteoside - High dose group (0.2 ml of 100 mg / ml verbascoside smeared; n=9). The medication group was given the drug 24 hours after the back hair removal, and the dilution of verbascoside and the external application of the model group and the blank group were all blank matrix (double distilled water: absolute ethanol: polyethylene glycol 400 = 5:3:2, v / v / v) 0.2ml, 1 time / d.

[0031] Preparation of androgenetic alopecia model in C57BL / 6J mice:

[0032] Use a shaver to shave the back hair of the mice in each group, with an area of ​​about 2cm × 3cm, and then apply a depilatory cream (Veting Gentle Depilatory Cream) to remove t...

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Abstract

The invention discloses an application of verbascoside in preparation of a medicine for treating androgenetic alopecia, and particularly relates to an application of verbascoside in preparation of a medicine for treating alopecia caused by testosterone. The verbascoside provided by the invention can effectively promote hair growth in an androgenetic alopecia area, is safe and effective, and has no adverse reaction; the verbasci can be extracted from plants, is wide in source, low in cost, economical and practical, and is convenient to take materials and low in cost when being used for preparing the medicine for treating the androgenetic alopecia.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of verbascoside in the preparation of drugs for treating androgenetic alopecia. Background technique [0002] Androgenetic alopecia (AGA), also known as "male pattern alopecia", "female diffuse alopecia" or "seborrheic alopecia", is an androgen-dependent, polygenetic and environmental factors hereditary diseases [1]. Androgenetic alopecia is the most important type of pathological alopecia. The symptoms are progressive hair loss and hair follicle atrophy. It is often accompanied by greasy head and dandruff. The itching can be mild to obvious, with a chronic course[2]. According to epidemiological statistics, the incidence rate of androgenetic alopecia among Asians is 73% [3]. Among men in European and American countries, nearly 30% of men suffer from androgenetic alopecia at the age of 30, 50% at the age of 50, and as high as 80% at the age of 70 [4-6]. In recent yea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P17/14A61P17/08
CPCA61K31/7032A61P17/14A61P17/08
Inventor 王志勇岳佳新王强强赵珍谢炜王娟
Owner SHANGHAI INST OF PHARMA IND CO LTD