Separable microneedle array capable of delivering medicine and performing in-vivo in-situ marking and preparation method of separable microneedle array

Abstract

The invention discloses a separable microneedle array capable of delivering drugs and labeling in vivo and in situ and a preparation method of the separable microneedle array in the field of preparation of microneedles capable of labeling in vivo and in situ and relates to a microneedle array which is loaded with drugs and fluorescent dyes, is prepared on the basis of a carboxymethyl cellulose (CMC) and sodium alginate (ALG) aqueous solution and has a relatively thick tip end and a relatively thin bottom end. The separable microneedle array with the in-vivo in-situ marking function for drug delivery provided by the invention has effective transdermal drug delivery capacity, information marking and storing functions and good biocompatibility; any number and pattern can be obtained by permutation and combination of the microneedle array, visual information marking is performed on the skin of a treated subject, and paperless recording is realized; meanwhile, in the application of treatment or prevention of administration, the wound on human skin is small, the pain degree is low, the acceptability of a subject to the microneedle administration mode is high, and the clinical transformation potential is high.

Description

technical field [0001] The invention relates to the technical field of preparation of microneedles that can be labeled in situ in vivo, in particular to a separable microneedle array that can be delivered and labeled in situ in vivo and a preparation method thereof. Background technique [0002] At present, the common methods of administration include oral administration and injection administration. When oral administration of drugs is performed, the first-pass elimination of the drug in the liver will greatly reduce the bioavailability of the drug. Injection administration is invasive and accompanied by pain. Children and some patients may be Needle panic, even needle dizziness. [0003] For patients who need multi-dose administration (repeated administration) or people who are vaccinated, clinical medical staff need to record the number of doses, but information may not be communicated between different medical units, and poor areas cannot use Internet information records...

AI Technical Summary

Problems solved by technology

[0003] For patients who need multiple doses of administration (repeated administration) or people who are vaccinated, clinical medical staff need to record the number of administrations, but different medical units may not communicate with each other, and Internet information records, paper records, etc. may not be available in poor areas. Quality version records are not easy to save and easy to lose

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