Antibacterial self-activation cascade reaction system HMPBNPs (at) GOx and preparation and application methods thereof

Abstract

The invention belongs to the field of nano materials, and particularly discloses an antibacterial self-activation cascade reaction system HMPBNPs (at) GOx as well as a preparation method and an application method of the antibacterial self-activation cascade reaction system HMPBNPs (at) GOx. Hollow Prussian blue with larger body surface area and higher peroxidase-like activity is prepared through a hydrothermal method, and then glucose oxidase is stirred and adsorbed to form a cascade reaction system. The cascade reaction system is activated by glucose to generate gluconic acid to adjust the pH value in the microenvironment from 7.0 to 3-4; meanwhile, generated H2O2 can be converted into hydroxyl free radicals (. OH) with higher antibacterial activity by hollow Prussian blue. The preparation method is simple and short in time, and the prepared composite material has more excellent antibacterial performance due to the synergistic effect of the hollow Prussian blue and the glucose oxidase and is good in biocompatibility, small in interference on normal physiological activities of body cells, low in toxicity and high in safety.

Description

technical field [0001] The invention belongs to the field of nanomaterials, and in particular relates to an antibacterial self-activation cascade reaction system HMPBNPs@GOx and a preparation and application method thereof. Background technique [0002] At present, wound infection and the resulting complications have become a worldwide problem and a major threat to global public health. Wound care and the economic burden it entails has become a major public health concern over the past few decades. The traditional treatment method for wound infection is to take or inject antibiotics. Rational use of antibiotics can control wound infection to the greatest extent, but the abuse of antibiotics has led to bacterial resistance. [0003] The development of nanomaterials provides an opportunity to develop new antibacterial agents. For example, the reported materials such as nano-silver have good antibacterial activity, and it is difficult to induce bacterial resistance. Because ...

AI Technical Summary

Problems solved by technology

[0005] Although nanozymes have been found to have good antibacterial activity in recent years, most nanozymes with peroxidase activity require the addition of H 2 o 2 Substrates can catalyze the formation of OH with high antibacterial activity

And directly quote the high concentration of H 2 o 2 Can cause damage to normal tissue due to its highly oxidative nature

The best working environment for nanozymes is an acidic environment, and its catalytic activity will be greatly limited in a neutral or alkaline environment

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