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Eye soothing smearing liquid and preparation method thereof

A technology for smearing liquid and eyes, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve eye inflammation, difficulty in resisting foreign bacteria, and human discomfort when using eye drops and other problems, to achieve the effect of fast absorption, repair of microcirculation, and obvious effect

Pending Publication Date: 2022-05-31
杭州美依生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when traditional products on the market are used, they need to be instilled into the eyes, which can easily cause irritation to the eyeballs and cause discomfort to the human body.
In addition, due to the special internal structure of the eye, it is more difficult to resist foreign bacteria than the skin. Improper use of eye drops can easily cause eye inflammation

Method used

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  • Eye soothing smearing liquid and preparation method thereof
  • Eye soothing smearing liquid and preparation method thereof
  • Eye soothing smearing liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0077] Embodiment 1A: low concentration atropine (0.1%)

[0078] An eye soothing smear solution, which is made by mixing phase A that can regulate eye microcirculation, intraocular pressure and relieve visual fatigue, phase B that can supplement eye nutrition, additives and purified water, wherein:

[0079] Phase A is by mass, including 0.1g of atropine;

[0080] Phase B includes the following components by mass: 1g vitamin A, 0.5g vitamin B1, 0.005g vitamin B2, 0.001g vitamin B12, 0.5g adenosine triphosphate, 1g bilberry seed oil and 0.001g lutein;

[0081] The auxiliary agent includes the following components in terms of mass: sodium hyaluronate 0.1g, exopolysaccharide 0.1g, hydrogenated castor oil 6g, cetyl ethylhexanoate 1g and phenoxyethanol 0.6g.

[0082] Purified water 89.093g.

[0083] The above components are divided into oil phase, water phase and added phase, as follows:

[0084] Water phase: 89.093g of purified water, 0.1g of atropine, 0.5g of vitamin B1, 0.005g...

Embodiment 1B

[0089] Embodiment 1B: high concentration atropine (2%)

[0090] Concrete components and preparation method of atropine smear solution (high concentration 2%) are consistent with above-mentioned embodiment 1A, just the concentration of atropine is high concentration, and the consumption of atropine is 2% (being 2g in the aqueous phase). Finally, a yellow liquid can be prepared.

[0091] Stability yields results such as Figure 8 .

[0092] Low-concentration atropine smear solution has obvious effect on relieving visual fatigue, but not on myopia; high-concentration atropine smear solution has obvious effect on relieving visual fatigue, but has obvious effect on myopia. After using the smear solution for about 4 weeks, the diopter of the left eye dropped from 350 degrees to 325 degrees degrees, down 25 degrees, right eye degree from 400 degrees to 375 degrees, down 25 degrees (see figure 1 ).

Embodiment 2A

[0093] Embodiment 2A: low concentration homatropine (0.1%)

[0094] An eye soothing smear solution, which is made by mixing phase A that can regulate eye microcirculation, intraocular pressure and relieve visual fatigue, phase B that can supplement eye nutrition, additives and purified water, wherein:

[0095] Phase A is by mass, including 0.1 g of homatropine;

[0096] Phase B includes the following components by mass: 1g vitamin A, 0.5g vitamin B1, 0.005g vitamin B2, 0.001g vitamin B12, 0.5g adenosine triphosphate, 1g bilberry seed oil and 0.001g lutein;

[0097] The auxiliary agent includes the following components in terms of mass: sodium hyaluronate 0.1g, exopolysaccharide 0.1g, hydrogenated castor oil 6g, cetyl ethylhexanoate 1g and phenoxyethanol 0.6g.

[0098] Purified water 89.093g.

[0099] The above components are divided into oil phase, water phase and added phase, as follows:

[0100] Water phase: 89.093g purified water, 0.1g homatropine, 0.5g vitamin B1, 0.005...

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Abstract

The invention aims to provide an eye soothing smearing liquid composition and a preparation method thereof, and the composition comprises a phase A capable of regulating eye microcirculation and intraocular pressure and relieving asthenopia, a phase B capable of supplementing eye nutrients, an auxiliary agent and purified water. Wherein the phase A comprises a Western medicine component I and a traditional Chinese medicine component II by mass, and the Western medicine component I comprises at least one of 0.1 g of atropine, 0.1 g of potropine and 0.1 g of tropicamide; the traditional Chinese medicine component II comprises at least one of 0.5 g of cassia seed extract, 0.5 g of mulberry leaf extract, 0.2 g of marigold flower extract, 0.5 g of albizia flower extract, 0.5 g of eyebright extract and 0.2 g of digitalis extract; the phase B is prepared from the following components by mass: 1g of vitamin A, 10.5 g of vitamin B1, 0.005 g of vitamin B2, 0.001 g of vitamin B12, 0.5 g of adenosine triphosphate, 1g of vaccinium myrtillus seed oil and 0.001 g of xanthophyll; and 1-100g of an auxiliary agent and 1-100g of purified water. The ointment has the advantages of external application, safety, no irritation and good effect.

Description

technical field [0001] The invention relates to the technical field of eye care, in particular to an eye soothing smear solution and a preparation method thereof. Background technique [0002] On May 31, 2021, "People's Daily" published an article "Preventing myopia and protecting minors from a better "vision" world". Early prevention, early care, and early treatment through routine inspections can effectively avoid eye diseases. At present, some countries are taking comprehensive measures to strengthen the prevention and control of myopia among minors. According to the "World Report on Vision" released by the World Health Organization, there are about 2.6 billion myopic people in the world, of which 312 million are under the age of 19. The myopia rate among children and adolescents has been increasing in recent years and will continue to increase significantly in the next few decades. The report analyzes that in modern society, people stay indoors for a long time to enga...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61K9/08A61K47/36A61P27/02A61P9/14A61K31/047A61K31/07A61K31/4409A61K31/46A61K31/51A61K31/525A61K31/7076A61K31/714
CPCA61K31/46A61K31/4409A61K36/482A61K36/605A61K36/28A61K36/48A61K36/80A61K31/525A61K31/714A61K31/047A61K31/07A61K31/51A61K31/7076A61K36/45A61K9/0048A61K9/08A61K47/36A61P27/02A61P9/14A61K2300/00Y02A50/30A61K31/05A61K47/44A61K36/355A61K36/8988A61K36/537A61K36/539A61K36/344A61K2236/39A61K9/008A61K36/185A61K36/21A61K36/43A61K45/06A61K47/10A61K47/12
Inventor 张伯科
Owner 杭州美依生物科技有限公司
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