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Artificial blood vessel with double functions of endothelialization promotion and anticoagulation as well as preparation method and application of artificial blood vessel

An artificial blood vessel, dual-function technology, applied in the field of artificial blood vessels, can solve the problems of reducing the mechanical properties of artificial blood vessels, low biocompatibility, performance differences, etc., to delay the appearance time limit, improve histocompatibility, and prevent thrombosis. Effect

Active Publication Date: 2022-06-03
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective way to prevent the occurrence of thrombosis in artificial blood vessels. Most of the methods to reduce the occurrence of thrombosis with drugs are to stick anticoagulant drugs on the inner wall of artificial blood vessels or directly wrap anticoagulant drugs in artificial blood vessel materials.
However, the anticoagulant drug coated on the inner wall of the artificial blood vessel is released at one time, and the period of preventing thrombosis is short; when the anticoagulant drug is wrapped in the artificial blood vessel material, there are many factors to be considered, which often reduces the mechanical properties of the artificial blood vessel.
[0004] The materials used to prepare artificial blood vessels have also exposed obvious performance differences
For example, polylactic acid and polycaprolactone are synthetic polymer biochemical materials. Although they have excellent mechanical properties and can be degraded in vivo, their biocompatibility is significantly lower than that of natural biomaterials.

Method used

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  • Artificial blood vessel with double functions of endothelialization promotion and anticoagulation as well as preparation method and application of artificial blood vessel
  • Artificial blood vessel with double functions of endothelialization promotion and anticoagulation as well as preparation method and application of artificial blood vessel
  • Artificial blood vessel with double functions of endothelialization promotion and anticoagulation as well as preparation method and application of artificial blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An artificial blood vessel with dual functions of promoting endothelialization and anticoagulation is prepared according to the following steps:

[0046] S1. Preparation of electrospinning solution:

[0047]Inner layer spinning solution: Weigh 0.04g pNSR16 (recombinant spider silk protein) and 0.96g PCL (polycaprolactone) respectively, and use 98% formic acid as a solvent to prepare a mixed electrospinning with a mass ratio of pNSR16 and PCL of 4:96. The solution is used as the inner layer spinning solution;

[0048] Outer layer spinning solution: Weigh 0.05g pNSR16 and 0.95g PLA (polylactic acid) respectively, and use 98% formic acid as a solvent to prepare a mixed electrospinning solution with a mass ratio of pNSR16 and PLA of 5:95 as the outer layer spinning solution;

[0049] S2. Preparation of artificial blood vessel inner layer

[0050] For electrospinning, the inner spinning solution was loaded into a 10 mL syringe equipped with a 10-gauge needle and injected a...

Embodiment 2

[0061] An artificial blood vessel with dual functions of promoting endothelialization and anticoagulation is prepared according to the following steps:

[0062] S1. Preparation of electrospinning solution:

[0063] Inner layer spinning solution: Weigh 0.04g pNSR16 (recombinant spider silk protein) and 0.60g PCL (polycaprolactone) respectively, and use 98% formic acid as a solvent to prepare a mixed electrospinning solution with a mass ratio of pNSR16 and PCL of 1:15. The solution is used as the inner layer spinning solution;

[0064] Outer layer spinning solution: Weigh 0.05g pNSR16 and 0.95g PLA (polylactic acid) respectively, and use 98% formic acid as a solvent to prepare a mixed electrospinning solution with a mass ratio of pNSR16 and PLA of 5:95 as the outer layer spinning solution;

[0065] S2. Preparation of artificial blood vessel inner layer

[0066] For electrospinning, the inner spinning solution was loaded into a 10 ml syringe equipped with a 10-gauge needle and ...

Embodiment 3

[0072] An artificial blood vessel with dual functions of promoting endothelialization and anticoagulation is prepared according to the following steps:

[0073] S1. Preparation of electrospinning solution:

[0074] Inner layer spinning solution: Weigh 0.04g pNSR16 (recombinant spidroin protein) and 1.40g PCL (polycaprolactone) respectively, and use 98% formic acid as solvent to prepare a mixed electrospinning with a mass ratio of pNSR16 and PCL of 1:35 The solution is used as the inner layer spinning solution;

[0075] Outer layer spinning solution: Weigh 0.05g pNSR16 and 0.95g PLA (polylactic acid) respectively, and use 98% formic acid as a solvent to prepare a mixed electrospinning solution with a mass ratio of pNSR16 and PLA of 5:95 as the outer layer spinning solution;

[0076] S2. Preparation of artificial blood vessel inner layer

[0077] For electrospinning, the inner spinning solution was loaded into a 10-ml syringe equipped with a 10-gauge needle and injected at a f...

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Abstract

The invention provides an artificial blood vessel, and particularly relates to an artificial blood vessel with double functions of endothelialization promotion and anticoagulation as well as a preparation method and application of the artificial blood vessel. According to the artificial blood vessel, RGD-pH response silicon dioxide drug-loaded nanoparticles are loaded on the outer wall of the inner layer of the artificial blood vessel, slow and stable release of drugs can be achieved under the normal pH of human blood, meanwhile, RGD polypeptide can induce ordered growth of endothelial cells, the silicon dioxide nanoparticles can also be degraded in vivo, and autologous blood vessel regeneration is facilitated; the loaded anticoagulant drug can prevent thrombosis in the artificial blood vessel for a long time, and the blood compatibility of the artificial blood vessel is improved.

Description

technical field [0001] The invention provides an artificial blood vessel, in particular to an artificial blood vessel with dual functions of promoting endothelialization and anticoagulation, a preparation method and application thereof, in particular, the artificial blood vessel is loaded with pH-responsive nanoparticles modified by RGD polypeptide, The anticoagulant drug rivaroxaban achieves its dual function. Background technique [0002] According to the data, cardiovascular disease is one of the diseases with high incidence and high mortality in the world. With the improvement of residents' living standards and the accelerated pace of life, the incidence of cardiovascular disease is also on the rise. In the clinical treatment of cardiovascular diseases, tissue engineering graft surgery is a common and effective treatment method; for patients who cannot complete autologous blood vessel transplantation, artificial blood vessel transplantation is an important alternative. ...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/30A61L27/34A61L27/50A61L27/54A61L27/58D04H1/728
CPCA61L27/507A61L27/26A61L27/34A61L27/54A61L27/306A61L27/58D04H1/728A61L2300/204A61L2300/42A61L2300/624C08L89/00C08L67/04C08L79/04
Inventor 赵亮潘玉雪李霞飞杜鹏翀孙路路
Owner XINXIANG MEDICAL UNIV
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