Alkaline fibroblast growth factor pellicle and its production method

A fibroblast and growth factor technology, applied in the field of basic fibroblast growth factor film and its preparation, can solve the problems of inconvenient use, poor adhesion of drug wounds, and difficult dosage control

Inactive Publication Date: 2004-09-01
ZHUHAI ESSEX BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned bFGF liquid preparation has the disadvantages that the dose is not easy to control, the drug has poor adhesion to the wound, and it is inconvenient to use after surgery.

Method used

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  • Alkaline fibroblast growth factor pellicle and its production method
  • Alkaline fibroblast growth factor pellicle and its production method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Embodiment: bFGF film for external use

[0031] 1. Prescription:

[0032] rb-bFGF 0.3mg

[0033] Human albumin 30mg

[0034] PVA-124 (polyvinyl alcohol) 10g

[0035] Glycerin 2g

[0036] Tween 80 2g

[0037] Mannitol 2g

[0038] Ethyl Paraben 20mg

[0039] Appropriate amount of distilled water

[0040] 2. Preparation method: (as shown in the picture)

[0041] (1) Disperse PVA in an appropriate amount of distilled water, fully swell, heat to dissolve completely, and then sterilize by autoclaving at 121°C for 30 minutes, and set aside.

[0042] (2) Dissolve the prescription amount of ethylparaben, Tween 80, mannitol and glycerin in an appropriate amount of distilled water, add bFGF stock solution and human serum albumin, and filter the solution aseptically with a 0.22 μm filter membrane.

[0043] (3) Add (2) into (1), and stir slowly.

[0044] (4) Use a film-forming mold to coat the film, put it into a freeze dryer at -40°C to 37°C, and freeze-dry it for 48 hour...

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PUM

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Abstract

An alkaline desmocyte growth factor film agent comprising, (1) alkaline desmocyte growth factor (bFGF) 0%-1% (W/W) of effective wound treatment dose, (2) medicinal film forming material 10%-90% (W/W), (3) medicinal findings 0%-50% (W/W), and the process of preparation comprises the steps of, dispersing the medicinal film forming material into distilled water, after sufficient swelling, heat pressing sterilization, dissolving the bFGF stock solution and medical dressing in distilled water, asepsis filtering, charging the filter liquor into disinfected film matrix, stirring slowly and evenly, the bFGF film agent can be obtained through film coating, drying and demoulding.

Description

technical field [0001] The invention relates to a basic fibroblast growth factor (Basic Fibroblast Growth Factor, referred to as bFGF) film and a preparation method thereof. The film can be used to treat various body surface injuries, gynecological diseases, various corneal diseases and oral ulcers. Background technique [0002] Basic fibroblast growth factor (bFGF) is a very small amount of polypeptide substances that exist in mammals and humans. bFGF can stimulate the division and proliferation of cells derived from mesoderm and ectoderm, such as fibroblasts, vascular endothelial cells, smooth muscle cells, corneal epithelial cells, lens epithelial cells, muscle cells, bone cells and nerve cells, so its physiological function is very important. Broadly, it is a multifunctional cell growth factor, which is clinically manifested as promoting the repair and healing of various tissue injuries. At present, basic fibroblast growth factor (bFGF) preparations that have been used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K38/18A61P1/02A61P15/00A61P17/02
Inventor 陈咏谭志刚
Owner ZHUHAI ESSEX BIO PHARMA
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