Compound with anti-neurodegenerative change activity as well as preparation method and application thereof

Abstract

The invention discloses a compound with anti-neurodegenerative change activity and a preparation method and application thereof. The compound with anti-neurodegenerative change activity can be produced by adopting a co-culture mode of two strains of alternaria brassicae and penicillium, and the capacity of microorganisms for synthesizing secondary metabolites is excavated as much as possible by virtue of research methods of changing a culture medium, culture conditions, a mixed culture ratio and the like. And scale-up culture can be carried out on the basis of repeatable and sustainable development of the process. The compound has neuroprotective activity on neurodegenerative change disease cells, and shows a better protective effect than a positive drug tert-butylhydroquinone (TBHQ).

Description

technical field [0001] The present application relates to the field of medical technology, in particular to compounds with anti-neurodegeneration activity, preparation methods and applications thereof. Background technique [0002] Neurodegenerative diseases are caused by the loss of neurons and / or their myelin sheaths, which worsen and become dysfunctional over time. Neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, affect many people worldwide, and the severity and severity of their symptoms have a dramatic impact on the quality of life of patients and their families. [0003] Clinical treatment of neurodegenerative diseases mainly includes surgery and chemotherapy. Surgical therapy has a high recurrence rate of postoperative disease, thus limiting its widespread use in the treatment of neurodegenerative diseases. In terms of drug treatment of neurodegenerative diseases, the existing drugs for Alzheimer's disease can only delay the deepening of pa...

AI Technical Summary

Problems solved by technology

[0004] At present, drugs for anti-neurodegenerative changes are mainly extracted and separated from natural products such as animal and plant medicines. The growth cycle is long and the raw materials are difficult to obtain. At the same time, the demand for a large number of raw materials may easily lead to resource scarcity or even exhaustion to varying degrees.

In addition, due to differences in production areas and animal and plant drugs that occur in different seasons, the active secondary metabolite components and contents are quite different, making it difficult to reproduce the active ingredients

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