High-efficiency permeable microemulsion as well as preparation method and application thereof

A microemulsion, high-efficiency technology, applied in the direction of medical preparations containing active ingredients, skin care preparations, pharmaceutical formulations, etc., can solve problems such as irritation, not suitable for sensitive skin, and no effect, and improve wrinkle removal ability , Improve the penetration effect, the effect of non-irritating skin

Pending Publication Date: 2022-06-10
ZHONGSHAN ZHONGYAN COSMETIC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polypeptide substances contained in this product are limited by their own penetration ability and lack of penetration-promoting substances. During use, the polypeptide substances are difficult to penetrate the skin, which reduces the use effect of the emulsion.
However, an increase in the dosage of the penetration aid will damage the skin barrier layer and cause irritation, so it is not suitable for sensitive skin, and a lower dosage will not achieve satisfactory results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The mass concentration of the acetyl hexapeptide-8 is 1000ppm, purchased from Nanjing Spike Biochemical Industry Co., Ltd.

[0039] The tetrahydropiperine was purchased from the Sabinsha company in the United States.

Embodiment 2

[0048] The mass concentration of the acetyl hexapeptide-8 is 1000ppm, purchased from Nanjing Spectra Biochemical Industry Co., Ltd.

[0049] The tetrahydropiperine was purchased from the Sabinsha company of the United States.

[0050] The sodium polyacrylate was purchased from BASF, Germany.

Embodiment 3

[0056] The mass concentration of the acetyl hexapeptide-8 is 1000ppm, purchased from Nanjing Spike Biochemical Industry Co., Ltd.

[0057] The tetrahydropiperine was purchased from the Sabinsha company in the United States.

[0058] The sodium polyacrylate is purchased from BASF, Germany.

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PUM

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Abstract

The preparation method comprises the following steps: performing high-pressure homogenization on polyglycerol-10 myristate, glycerol, squalane, potassium cetyl phosphate, tetrahydropiperine and deionized water, mixing with deionized water, 1, 3-butanediol, sodium hyaluronate, sodium polyacrylate and EDTA-2Na (Ethylene Diamine Tetraacetic Acid), adding acetyl hexapeptide-8 and phenoxyethanol, performing uniform stirring, and performing uniform stirring to obtain the microemulsion. And preparing to obtain the emulsion. The prepared emulsion is milder, has no irritation to skin, and has a good wrinkle removing effect.

Description

A kind of high-efficiency permeable microemulsion and its preparation method and application technical field The invention belongs to A61Q19 / 08 field, be specifically related to a kind of microemulsion of efficient penetration and preparation method and application thereof use. Background technique Polypeptide actives have extremely high activity, and can promote various functions such as body regeneration, cell metabolism, etc. It is an important active substance in the human body. In the field of skin care products, peptide actives are often added to achieve the purpose of rejuvenating the skin. of. [0003] Chinese patent CN110151597A discloses a kind of emulsion containing polypeptide, after mixing a variety of polypeptide substances, adding into a solution composed of raw materials such as propylene glycol and allantoin, and stir evenly to obtain a polypeptide emulsion. But this product contains Due to the limitation of their own penetration ability and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/49A61K8/55A61K8/31A61K8/34A61K8/73A61K8/06A61Q19/08
CPCA61K8/64A61K8/49A61K8/55A61K8/31A61K8/345A61K8/735A61K8/06A61Q19/08A61K2800/805
Inventor 莫美玲杨一帆
Owner ZHONGSHAN ZHONGYAN COSMETIC CO LTD
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