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Application of plasminogen in preparation of medicine for promoting angiogenesis

A technology of angiogenesis and plasminogen, which is applied in the direction of drug combination, cardiovascular system diseases, medical preparations containing active ingredients, etc. Lysogen promotes angiogenesis and other problems, to achieve the effect of treating cerebral infarction, accelerating the recovery of motor and sensory functions, and promoting the regeneration of brain blood vessels

Pending Publication Date: 2022-06-21
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] At present, there is no report about plasminogen promoting angiogenesis, let alone a report about plasminogen promoting cerebral angiogenesis

Method used

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  • Application of plasminogen in preparation of medicine for promoting angiogenesis
  • Application of plasminogen in preparation of medicine for promoting angiogenesis
  • Application of plasminogen in preparation of medicine for promoting angiogenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Cerebral infarction surgery experiment in normal mice and plasminogen knockout mice

[0028] 1. Method

[0029] The plasminogen gene knockout mice were constructed, and the middle cerebral artery infarction was performed with the normal mice, and the cerebral infarction was modeled.

[0030] The modeling method is as follows:

[0031] (1) The mice of the corresponding genotype were continuously anesthetized with trifluorobromochloroethane gas. Sutures for ligating or blocking arteries are prepared in advance and infiltrated in normal saline.

[0032] (2) After a few minutes, if the mouse cannot turn over freely, it is considered that the depth of anesthesia has been reached. The mouse is bound on the dissection table, and a cotton swab is placed under the mouse's neck to pad it. Iodophor sterilizes the mouse's neck and Prepare the skin.

[0033] (3) Cut the skin along the middle of the mouse neck, bluntly separate the subcutaneous tissue and fat with ophth...

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Abstract

The invention discloses application of plasminogen to preparation of a medicine for promoting angiogenesis, and belongs to the field of the medicine for promoting angiogenesis. The invention discloses the angiogenesis promoting effect of plasminogen for the first time, and the plasminogen is prepared into the medicine, so that cerebrovascular neogenesis can be remarkably promoted, and a cerebral infarction patient is helped to recover movement and sensory functions more quickly.

Description

technical field [0001] The invention belongs to the field of angiogenesis-promoting drugs. Background technique [0002] A stroke, commonly known as a stroke, is damage to the brain tissue caused by damage to the blood vessels in the brain. Stroke is the most common cause of disability and a common cause of death in developed countries. In my country, stroke is the first cause of death and disability in adults, and it has the characteristics of high morbidity, high disability rate, high mortality rate and high recurrence rate. Stroke is generally divided into two categories, namely ischemic stroke and hemorrhagic stroke. Ischemic stroke, also known as cerebral infarction, accounts for about 70% of strokes in my country. [0003] Drug-assisted cerebral angiogenesis can reduce ischemic injury, promote the recovery of neurological function in ischemic areas, and improve prognosis. The drugs that promote angiogenesis mainly include: statins, angiotensin receptor inhibitors, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P9/10A61P9/14
CPCA61K38/484A61P9/10A61P9/14C12Y304/21007
Inventor 方婧环
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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