Tumor specific promoter and application thereof
A promoter and promoter element technology, applied in the field of tumor-specific promoters, can solve problems such as difficult to obtain good results and limited activity, and achieve the effect of inhibiting tumor growth and improving the function of tumor-specific promoters
Pending Publication Date: 2022-07-05
SICHUAN UNIV
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Abstract
The invention belongs to the field of tumor immunotherapy, and particularly relates to a tumor specific promoter and application thereof. The technical problem to be solved by the invention is that the tumor specific multiplication capacity of the oncolytic adenovirus is limited. According to the scheme for solving the problems, the core promoter is provided, has the function of independently promoting gene expression, can be independently used as a promoter and can also be used as a component construction promoter. The nucleotide sequence of the gene is as shown in SEQ ID No. 1; or a nucleic acid molecule which is obtained by inserting, deleting and/or replacing one or more basic groups in the nucleotide sequence as shown in the sequence SEQ ID No.1 and still has the promoter function, wherein the nucleotide sequence is obtained by inserting, deleting and/or replacing one or more basic groups in the nucleotide sequence as shown in the sequence SEQ ID No.1. The modified tumor specific promoter has a better tumor specific promoter function, and the oncolytic adenovirus constructed by the promoter has the characteristic of being capable of specifically proliferating in tumor cells but not proliferating in normal cells, and is an excellent immunotherapy drug aiming at various tumors.
Application Domain
VectorsTransferases +8
Technology Topic
Gene expressionTumor specific +14
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