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Application of tetrahydroxanthone dimer compound in preparation of antitumor drugs

A technology of tetrahydroxanthone dimer and xanthone dimer, applied in the field of anti-tumor drugs, can solve the problems of patient side effects and poor prognosis, and achieve the effect of significant anti-tumor activity

Pending Publication Date: 2022-07-08
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Tumor is the second largest killer of human health next to cardiovascular and cerebrovascular diseases. In China's first- and second-tier cities, the number of cancer deaths ranks first among all causes of death. Existing treatments generally have relatively large side effects and Poor prognosis

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  • Application of tetrahydroxanthone dimer compound in preparation of antitumor drugs
  • Application of tetrahydroxanthone dimer compound in preparation of antitumor drugs
  • Application of tetrahydroxanthone dimer compound in preparation of antitumor drugs

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Embodiment Construction

[0041] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0042] The experimental methods used in the embodiments of the present invention are conventional methods unless otherwise specified.

[0043] Materials, reagents, etc. used in the examples of the present invention can be obtained from commercial sources unless otherwise specified.

[0044] 1. Research methods

[0045] 1.1 Source of strain

[0046] The endophytic fungus Phomopsis asparagi was collected from the genus Phomopsis of the mangrove tree in Hainan Province. Through the observation of the morphological characteristics of the strain and the use of molecular biology methods (ITS-rDNA sequence alignment), the strain was finally identified as Phomopsis sp., which is now preserved in the China Collection of Type Cultures (CCTCC) (PDA medium, -20°C) save). The endophytic fungus Phomopsis asparagi was ...

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Abstract

The invention provides an application of a tetrahydroxanthone dimer compound in preparation of an antitumor drug. The structural formula of the tetrahydroxanthone dimer compound is as shown in (1): R = H or Ac. A histone deacetylase inhibitor sodium butyrate is added into mangrove forest endophytic fungi Phomopsis asparagi DHS-48, two tetrahydroxanthone dimer compounds dicerantrol A (DD-38) and dicerantrol C (DD-9) are separated from a rice culture fermentation product, and the structures of the tetrahydroxanthone dimer compounds are characterized by applying technologies such as mass spectrum, nuclear magnetic resonance spectrum and ultraviolet spectrum. Experiments prove that the compound has remarkable anti-tumor activity and can be used for preparing anti-liver cancer and anti-cervical cancer drugs targeting a Wnt / beta-catenin signal channel.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to the application of tetrahydroxanthone dimer compounds in the preparation of antitumor drugs. Background technique [0002] Tumors are the second biggest killer of human health after cardiovascular and cerebrovascular diseases, and the number of cancer deaths in first- and second-tier cities in China ranks first among all causes of death. Poor prognosis. The Wnt / β-catenin signaling pathway plays an important role in the regulation of apoptosis, and the discovery of natural small-molecule compounds that can specifically inhibit the Wnt signaling pathway and activate tumor cell apoptosis is of great importance for the development of drug-targeted delivery of anti-tumor drugs. significance. SUMMARY OF THE INVENTION [0003] In view of this, the present invention proposes the application of tetrahydroxanthone dimer compounds in the preparation of antitumor drugs. [0004] The techn...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00C07D311/86C12P17/06C12R1/645
CPCA61K31/352A61P35/00C07D311/86C12P17/06Y02A50/30
Inventor 徐静周董董冯婷韦成文
Owner HAINAN UNIVERSITY