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Composition of wogonin and irinotecan and application of composition in preparation of anti-colorectal cancer drugs

A kind of technology of irinotecan and wogonin, applied in the field of medicine

Pending Publication Date: 2022-07-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no research at home and abroad that shows that wogonin and irinotecan have synergistic colon cancer activity, and there is no report on the combination of wogonin and irinotecan for the preparation of anti-colorectal cancer drugs

Method used

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  • Composition of wogonin and irinotecan and application of composition in preparation of anti-colorectal cancer drugs

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Experimental program
Comparison scheme
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Embodiment Construction

[0015] The substantive content of the present invention is specifically described below in conjunction with the examples, but the protection scope of the present invention is not limited by this.

[0016] 1. Experimental materials

[0017] Reagents: DMSO (Sigma-Aldrich, USA); penicillin-streptomycin (Hyclone, USA); 0.5% pancreatin-EDTA solution (Boster, Wuhan Boster Biological Engineering Co., Ltd.); PBS solution (Hyclone, USA); FBS (Gibco, USA); DMEM medium (Gibco, USA), MTT (Jiangsu Kage Biotechnology Co., Ltd.).

[0018] Consumables: 100mm cell culture dish, cell cryopreservation tube, 96-well plate (Corning, USA), 15ml / 50ml centrifuge tube (Guangzhou Jiete Biofiltration Co., Ltd.).

[0019] Drugs: wogonin (CAS: 632-85-9) was purchased from Chengdu Refensi Biotechnology Co., Ltd., purity: 99%; Irinotecan (CAS: 97682-44-5) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. Ltd., Purity: 99%.

[0020] Cell: Human colon cancer cell HCT116 (purchased from N...

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Abstract

The invention discloses a wogonin and irinotecan composition and application of the wogonin and irinotecan composition in preparation of anti-colorectal cancer drugs. According to the wogonin and irinotecan composition provided by the invention, the two chemical components in the composition have an obvious synergistic effect in the anti-colorectal cancer aspect, and the unexpected technical effect of 1 + 1 > 2 is generated, so that the wogonin and irinotecan composition has the prospect of being developed into anti-colorectal cancer medicines.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition of wogonin and irinotecan and its application in preparing an anti-colorectal cancer drug. Background technique [0002] Colorectal cancer (CRC) is one of the most morbid and lethal cancers in the world, and the fourth leading cancer type in the world. According to epidemiological statistics, in 2020, there will be 1.93 million new diagnoses of CRC worldwide (accounting for about 10%, ranking third), and 940,000 deaths (accounting for about 9.4%, ranking second), with rapid growth and The trend of youth is a serious threat to human health. Surgery is still the most effective treatment, but there is still a risk of recurrence and metastasis. Radiotherapy and chemotherapy as adjuvant therapy for surgery can reduce the local recurrence rate, but can cause adverse reactions such as vomiting, enteritis, hair loss, anorexia, leukopenia, and decreased immunity. Altho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61P35/00A61K31/352
CPCA61K31/352A61K31/4745A61P35/00A61K2300/00
Inventor 张培周鸿艳许风国杨柳张尊建
Owner CHINA PHARM UNIV