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Synthesis method of tumor radiotherapy material

A synthesis method and technology for tumor radiotherapy, which is applied in the field of synthesis of tumor radiotherapy materials, can solve problems such as poor absorption effect, small toxic and side effects, and large toxic and side effects, and achieve good radiotherapy sensitization effects, reduce toxic and side effects, and stable properties Effect

Pending Publication Date: 2022-07-29
HUAIBEI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the poor absorption effect of radiosensitizers on X-rays and the problem of serious side effects, the purpose of the present invention is to provide a synthesis method for tumor radiotherapy materials, which has a strong absorption effect of radiosensitizers on X-rays , and less toxic side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for synthesizing a material for tumor radiotherapy, the steps comprising:

[0026] S1. Pulverize wolframite ore to 300 mesh, remove impurities from wolframite ore, then add wolframite ore to 1.5 times the amount of caustic soda to obtain sodium tungstate, add calcium chloride to sodium tungstate to synthesize tungstic acid calcium;

[0027] S2, place calcium tungstate and ultrapure water in the reactor, stir and dissolve for 60min at a rotating speed of 600r / min to obtain aqueous solution A;

[0028] S3, add gadolinium salt aqueous solution in the reaction kettle, stir and react 60min with the rotating speed of 600r / min, obtain gadolinium tungstate solution;

[0029] S4, cooling the gadolinium tungstate solution to room temperature, crystallizing, recrystallizing, and filtering to obtain gadolinium tungstate crystals, rinse the gadolinium tungstate crystals with ultrapure water, and then dry them;

[0030] S5, adding glycerol, divalent manganese, and silicon ...

Embodiment 2

[0040] A method for synthesizing a material for tumor radiotherapy, the steps comprising:

[0041] S1. Pulverize wolframite ore to 320 mesh, remove impurities from wolframite ore, then add wolframite ore to 1.5 times the amount of caustic soda to obtain sodium tungstate, add calcium chloride to sodium tungstate to synthesize tungstic acid calcium;

[0042] S2, place calcium tungstate and ultrapure water in the reactor, stir and dissolve for 100min at a rotating speed of 800r / min to obtain aqueous solution A;

[0043] S3, add gadolinium salt aqueous solution in the reaction kettle, stir and react 100min with the rotating speed of 800r / min, obtain gadolinium tungstate solution;

[0044] S4, cooling the gadolinium tungstate solution to room temperature, crystallizing, recrystallizing, and filtering to obtain gadolinium tungstate crystals, rinse the gadolinium tungstate crystals with ultrapure water, and then dry them;

[0045] S5, adding glycerol, divalent manganese, and silico...

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Abstract

The invention discloses a synthesis method of a tumor radiotherapy material, which comprises the following steps: S1, grinding wolframite to 300-320 meshes, adding the wolframite into caustic soda to obtain sodium tungstate, and adding calcium chloride into the sodium tungstate to synthesize calcium tungstate; s2, putting calcium tungstate and ultrapure water into a reaction kettle, and stirring and dissolving for 60-100 minutes at the rotating speed of 600-800r / min to obtain an aqueous solution A; s3, adding a gadolinium salt aqueous solution into the reaction kettle, and stirring and reacting for 60-100 minutes at the rotating speed of 600-800r / min to obtain a gadolinium tungstate solution. According to the synthesis method of the material for tumor radiotherapy, X-rays are absorbed through gadolinium tungstate, and gadolinium and tungsten atoms have high atomic numbers and have high absorption capacity on the X-rays, so that the gadolinium polytungstate nanocluster has a good radiotherapy sensitization effect; meanwhile, the properties of gadolinium and tungsten are stable, the size of the gadolinium tungstate nanocluster is very small, and the gadolinium tungstate nanocluster can be quickly discharged out of a body through a kidney, so that toxic and side effects caused by long-term accumulation of the gadolinium tungstate nanocluster in the body are greatly reduced, and the effect of the gadolinium tungstate nanocluster is

Description

technical field [0001] The invention relates to the technical field of tumor radiotherapy, in particular to a method for synthesizing a material for tumor radiotherapy. Background technique [0002] Radiation therapy is one of the three main treatment strategies for the clinical treatment of local solid tumors. More than 50% of patients received radiation therapy during the cancer fight; however, high-intensity radiation during the treatment process can not only kill tumor cells, but also It will also cause inevitable damage to the surrounding normal tissues; therefore, how to develop a radiosensitizer with excellent performance to maximize the radiation dose to cancer cells and reduce the damage to normal cells has become an urgent problem to be solved; [0003] After searching, the invention patent with Chinese patent number 201910508639.3 discloses an atomically precise nano-gold cluster material radiosensitizer, which belongs to the intersection of nanomaterial chemistry...

Claims

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Application Information

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IPC IPC(8): C01G41/00A61K41/00A61P35/00
CPCC01G41/00A61K41/0038A61P35/00
Inventor 李朋朱才勇
Owner HUAIBEI NORMAL UNIVERSITY