Pyrroloquinoline quinone derivative or medicinal salt thereof, preparation method and application
A technology of pyrroloquinoline quinone and its derivatives, which is applied in the field of biomedicine, can solve problems affecting drugability, etc., and achieve excellent solubility and ideal drug efficacy
Pending Publication Date: 2022-07-29
CHINA PHARM UNIV
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The invention discloses a pyrroloquinoline quinone derivative with a structure as shown in a formula (I) or a medicinal salt thereof, a preparation method and application of the pyrroloquinoline quinone derivative. The derivative has excellent solubility and/or permeability, is obviously superior to PQQ and PQQ salt (commercially available disodium salt), shows an ideal drug effect in anti-inflammatory, anti-diabetes and anti-metabolic disease models, and is superior to PQQ and PQQ salt (commercially available disodium salt). The invention also provides a preparation method of the derivative and an intermediate thereof, a pharmaceutical composition and medical application thereof.
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