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Compositions with specific insoluble to soluble fiber ratios for treatment of e.g. Anxiety

A soluble, compositional technology for use in the treatment of anxiety or stress in animals, growth and inhibition of growth of non-beneficial microorganisms, formulations for the treatment of dogs, compositions for the treatment of anxiety or stress in animals, prevention of 4-EPS levels in animals Elevated domains, which address issues such as increased likelihood of aggressive behavior, increased excitement, etc.

Pending Publication Date: 2022-07-29
HILLS PET NUTRITION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Stress has the potential to cause disease, suppress the immune system, induce undesirable behaviors, and heighten arousal, which increases the likelihood of aggressive behavior

Method used

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  • Compositions with specific insoluble to soluble fiber ratios for treatment of e.g. Anxiety
  • Compositions with specific insoluble to soluble fiber ratios for treatment of e.g. Anxiety
  • Compositions with specific insoluble to soluble fiber ratios for treatment of e.g. Anxiety

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0083] Preparation of the composition

[0084] Compositions comprising n-3 fatty acids, antioxidants, insoluble fiber, and soluble fiber as outlined above can be prepared as food products suitable for consumption by dogs. These food products can be of any consistency or moisture content; that is, the composition can be a moist, semi-moist or dry food product. A "moist" food product is generally one that has a moisture content of 60% to 90% or more. A "dried" food product is typically a food product with a moisture content of 3% to 11%, and is usually manufactured in the form of small pieces or kibble. A "semi-moist" food product typically has a moisture content of 25% to 35%. Food products may also include components having more than one consistency, such as soft, chewy meat-like particles or pieces, and kibble having an outer cereal component or coating and an inner "cream" component.

[0085] In some embodiments, food products of n-3 fatty acids, antioxidants, insoluble f...

Embodiment 1

[0095] The microbial metabolite 4-ethylphenyl sulfate (4-EPS) is associated with stress and anxiety. The level of 4-EPS in the blood can be measured. Blood was collected for determination of plasma metabolomic profiles. Levels of 4-EPS in plasma can be measured by commercial laboratories (Metabolon, Durham, NC, USA). The extracted supernatants were separated and run on gas chromatography and liquid chromatography mass spectrometer platforms. The peak value of 4-EPS is known, and the area under the peak for each sample can be normalized relative to known samples (see also: Evans, A.M. et al. (2009), for identification of small molecule complement in biological systems and Integrated, nontargeted ultrahighperformance liquid chromatography / electrospray ionization tandem massspectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems, analysis Chem. 81, 6656-6667). Gas chromatography (for hydrophobic molecules...

Embodiment 2

[0108] The following composition is based on the total nutrition provided per day.

[0109] In some embodiments, the amount of n-3 fatty acids is equal to 0.6-0.9% of the daily nutrient intake on a dry matter basis based on the total weight of the composition, the amount of vitamin C is greater than 400 ppm of the daily nutrient intake, the vitamin The amount of E is above the daily nutrient intake of 1000 IUK, the amount of insoluble fiber and soluble fiber is equal to about 4.0-6.0% and the ratio (insoluble fiber / soluble fiber) is in the range between 2.0 and 3.0. In some embodiments, based on the total weight of the composition on a dry matter basis, the composition comprises: chicken in an amount of 5% to 25%; egg protein in an amount of 4% to 15%; egg protein in an amount of 6% to 20% corn gluten meal; vegetables in an amount of 0.5% to 2%; fruit in an amount of 0.5% to 2%; Carbohydrates from rice, hulled oats, and their combinations.

[0110] In some embodiments, the a...

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PUM

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Abstract

Compositions and methods for treating anxiety or stress in an animal are disclosed. Compositions and methods for reducing an elevated level of 4-EPS or preventing an elevated level of 4-EPS are disclosed. Compositions and methods for promoting the growth of beneficial microorganisms and inhibiting the growth of non-beneficial microorganisms in an animal microbiota are disclosed. The method comprises administering to the animal an effective amount of an n-3 fatty acid, an antioxidant, insoluble fibers in an effective insoluble fiber to soluble fiber ratio, and soluble fibers. The composition includes an effective amount of an n-3 fatty acid, an antioxidant, insoluble fibers and soluble fibers in an effective insoluble fiber to soluble fiber ratio.

Description

Background technique [0001] The microbial toxin 4-ethylphenyl sulfate (4-EPS) is a metabolite produced by gut microbes. Among other microbial metabolites, 4-EPS enters the systemic circulation. In canines in particular, increased blood levels of 4-EPS have been associated with stress, anxiety, brain damage and other behavioral problems. Reduction in 4-EPS levels has been shown to relieve symptoms of stress and anxiety. [0002] Canine anxiety (anxiety) is a response to fear and agitation, or worry when a dog anticipates a threatening or fearful situation. Some individual dogs experience disproportionate levels of anxiety. Anxiety can develop into an anxiety disorder and can lead to behavioral and other problems. Some dogs experience generalized anxiety, in which fear responses manifest in a variety of situations where a "normal" pet is unlikely to respond. Anxiety can manifest as one of several anxiety disorders, such as generalized anxiety disorder, hyperstimulation anxi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K10/30A23K20/158A23K50/42A61K31/202A23K20/163A61K31/355A61K31/375A61K31/717A61P25/00A61P25/22
CPCA23K10/30A23K20/158A61K31/202A61K31/355A61K31/375A61K31/717A23K50/40A23K20/174
Inventor 伊登·伊弗雷姆丹尼斯·朱厄尔
Owner HILLS PET NUTRITION INC