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Hyperspectral brain blood oxygen detection system and method

A detection system and cerebral blood oxygen technology, which are applied in the field of hyperspectral cerebral blood oxygen detection system, can solve the problems of low spectral resolution and measurement accuracy, and solve the problems of low spectral resolution and measurement accuracy, improve accuracy, and improve The effect of sensitivity

Pending Publication Date: 2022-08-05
HRG INT INST FOR RES & INNOVATION
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is how to solve the technical problem of low spectral resolution and measurement accuracy existing in the prior art

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  • Hyperspectral brain blood oxygen detection system and method
  • Hyperspectral brain blood oxygen detection system and method
  • Hyperspectral brain blood oxygen detection system and method

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Experimental program
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Embodiment 1

[0048] like figure 1 As shown, the system consists of 700-900nm broad-spectrum LED light source, light source detector, filter set, turntable, data collector and so on. The light source emits near-infrared light to a specific brain area, and the light is scattered in a banana-shaped path. The light source detector located 2-7cm away from the beam can collect the light scattered by the tissue, in order to obtain the oxyhemoglobin and deoxyhemoglobin concentrations more accurately. 12 wavelengths in the range of 700-900nm are used to divide the results into 6 groups to solve the result. The filter group is loaded on the turntable, and the narrow-band filter is rotated at the front end of the detector to realize the capture of 12 wavelength signals. When the distance between the light source and the detector was set at 4 cm, the fNIRS signal was particularly sensitive to light scattered by oxyhemoglobin at 2–3 mm of the cortical surface.

[0049] like Figure 2 to Figure 3 As s...

Embodiment 2

[0056] In this embodiment, for example, a method of measuring the blood oxygen concentration with two channels can be used to select a wavelength above and below 805 nm (isosbestic point) for measurement. In brain imaging, a modified version of the Beer-Lambert law (mBLL) is used, which can be used to calculate the relative concentration of hemoglobin as a function of the total photon traversal path length. Typically, the light emitter and detector are placed on the same side of the subject's skull, and the optimal distance for detection is currently around 3 cm, so the recorded measurements are due to scattering after an elliptical path (also called a photon banana) ( reflected light. The specific formula is:

[0057]

[0058] Where OD=A, ε is the attenuation coefficient, Δ[X] is the corresponding concentration, and d is the detection distance. OD, ε, and d are all known, so Δ[X] can be obtained Hb with Δ[X] HbO2 . When the system is adopted, 6 sets of data can be use...

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Abstract

The invention provides a hyperspectral brain blood oxygen detection system and method. The hyperspectral brain blood oxygen detection system comprises a light source, a processor and a processor, the controller is respectively coupled with the light source detector, the turntable and the data collector, and the controller is used for generating and sending a time sequence pulse signal to the light source detector; the light source detector is arranged on a detected tissue, and a preset scattering acquisition distance is spaced between the installation position of the light source detector and the detected tissue; the optical filter group is loaded on the turntable, and the optical filter group comprises optical filters with at least two wavelengths; the data acquisition unit is a multi-wavelength photosensitive processing assembly; and the data processor divides the multi-wavelength hemoglobin detection response curve into at least two groups according to at least two wavelengths in a preset wavelength interval, and processes the multi-wavelength hemoglobin detection response curve to obtain a hyperspectral brain blood oxygen detection result. The technical problem that the spectral resolution and the measurement precision are low is solved.

Description

technical field [0001] The invention relates to photoelectric detection / biomedical detection equipment, in particular to a hyperspectral cerebral blood oxygen detection system and method. Background technique [0002] Functional near-infrared spectroscopy (fNIRS) is a non-invasive, cost-effective, low-noise, easy-to-use and continuously measurable optical brain imaging technology. Broad application prospects. fNIRS utilizes the light penetration of brain tissue and the specific absorption of certain chromophores in blood tissue to specific spectrum of near-infrared light to measure oxyhemoglobin and deoxyhemoglobin, which are closely related to the energy supply and metabolism of cerebral cortex activities, and then Obtain the indicators of hemodynamic changes in cerebral cortex tissue. Compared with functional magnetic resonance imaging (fMRI), fNIRS has higher temporal resolution (several milliseconds to tens of milliseconds), has less restriction on the subjects' physic...

Claims

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Application Information

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IPC IPC(8): A61B5/1455A61B5/00
CPCA61B5/14553A61B5/14552A61B5/14557A61B5/0042A61B5/0075A61B2576/026
Inventor 王卓胡晓军陈光于振中何雷曹玉君张鹏飞于家伟郑鑫
Owner HRG INT INST FOR RES & INNOVATION