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System for detecting electromagnetic exposure cell biological effect in vitro

A technology of cell biology and effect, applied in the field of electromagnetic radiation biological effect, can solve the problems of expensive, time-consuming, and high consumption of reagents, and achieve the effect of good uniformity, accurate measurement results, and clear direction of electromagnetic field

Active Publication Date: 2022-08-09
EAST CHINA NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem is that most efforts to address the relationship between RF-EMFs and biological effects have relied on in vivo experiments or via cell-based models in petri dishes, which are either time-consuming, expensive, or reagent-intensive, and can only satisfy low-throughput analysis

Method used

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  • System for detecting electromagnetic exposure cell biological effect in vitro
  • System for detecting electromagnetic exposure cell biological effect in vitro
  • System for detecting electromagnetic exposure cell biological effect in vitro

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Umbilical vein endothelial cells (HUVEC) were detected using a system for detecting biological effects of electromagnetically exposed cells in vitro. The parameters of electromagnetic radiation were set as: frequency band: 1.8 GHz; type: continuous wave; electromagnetic irradiation time: 30 minutes; the generated in vitro cells Migration effect.

[0046] see figure 1 , figure 2 , image 3 , the process is: First, the parameter setting of the RF generator 12 and the construction of the related platform. Specifically, the radio frequency generator 12 is controlled by wireless programming through the computer 11 control software LabVIEW, and the parameters of electromagnetic radiation are set as: frequency band: 1.8 GHz; type: continuous wave; electromagnetic radiation time: 30 minutes.

[0047] see figure 1 , figure 2 , image 3 , build the microfluidic assembly 2 , the incubation box 31 and build the test device 4 . The electromagnetic field radiation generating...

Embodiment 2

[0052] Using a system for detecting the biological effects of electromagnetically exposed cells in vitro to detect the electromagnetic radiation parameters of human amniotic epithelial cells: frequency band: 4.8GHz; type: pulse wave; electromagnetic irradiation time: 1 hour; quantitative expression.

[0053] see figure 1 , figure 2 , image 3 , the process is: RF generator 12 parameter setting and related platform construction. Specifically: firstly, the radio frequency generator 12 is controlled by wireless programming through the computer 11 control software LabVIEW, the parameters of electromagnetic radiation: frequency band: 4.8GHz; type: pulse wave; electromagnetic radiation time: 1 hour. Build the microfluidic assembly 2 , the incubation box 31 and build the test device 4 . The electromagnetic field radiation generating device 1 and the testing device 4 are arranged in the outer space of the incubation box 31 ; the microfluidic component 2 , the electric field measu...

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Abstract

The invention discloses a system for detecting the biological effect of electromagnetically exposed cells in vitro, a novel irradiation system of a single-pole radio frequency antenna coupled micro-fluidic chip is generated by combining a micro-fluidic assembly and a cell incubator, a controllable electromagnetic field radiation environment is generated by an electromagnetic field radiation generating device, and the biological effect of the electromagnetically exposed cells can be detected in vitro. The unipolar transmitting antenna is coupled with the micro-fluidic chip of the micro-fluidic assembly to radiate an electromagnetic field to the micro-fluidic chip, so that uniform distribution of a gradient electric field in a micro-cavity in the micro-fluidic chip is realized in a multi-frequency range and a multi-waveform mode, and the requirements of accurate detection and high-throughput analysis of an electromagnetic biological effect are met; the invention provides a research method for detecting the biological effect of the electromagnetic exposure cells in vitro, and the research method has the advantages of short time consumption, low price, low reagent consumption and capability of meeting high-throughput analysis.

Description

technical field [0001] The invention relates to the technical field of electromagnetic radiation biological effects, in particular to a system for detecting the biological effects of electromagnetically exposed cells in vitro. Background technique [0002] With the proliferation of wireless communication devices, the widespread use of cell phones inevitably draws public attention to the potential adverse biological effects of exposure to radio frequency electromagnetic fields. With the development of science and technology, researchers have gradually deepened the scientific understanding of the biological effects induced by radio frequency electromagnetic fields. At present, experts in bioelectromagnetics at home and abroad have carried out a large number of studies on the biological effects of electromagnetic radiation on cells, which has accelerated the accumulation of scientific knowledge about the response of biological cells to external electric fields. The problem is ...

Claims

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Application Information

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IPC IPC(8): C12M3/04C12M1/42C12M1/36C12M1/34
CPCC12M23/16C12M35/02C12M41/46C12M41/48B01L3/5027Y02A50/30
Inventor 王梦双李欣张杰王向晖齐红新陈廷芳
Owner EAST CHINA NORMAL UNIVERSITY
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