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Spectiogram biological chip detector

A biochip and detector technology, which is applied in the field of detection devices for biochips using spectral imaging technology, can solve problems such as inapplicability to biochips, large structure, and difficulty in distinguishing, and achieve the effects of light weight, small size and low cost.

Inactive Publication Date: 2004-11-03
蔡静军
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  • Abstract
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  • Application Information

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Problems solved by technology

[0009] Compared with the spectral imaging detection method, although the existing light-excited fluorescence detection method has simple advantages, it has obvious disadvantages: in principle, f(λ) and g(λ) may be easily distinguished, and ∫f( λ)dλ and ∫g(λ)dλ become indistinguishable
The structure of this spectroscopic imager is very bulky, and it is not suitable for the detection of biochips

Method used

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  • Spectiogram biological chip detector
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Embodiment Construction

[0025] A kind of spectrum image biochip detector designed by the present invention is described in detail as follows in conjunction with embodiments and accompanying drawings:

[0026] Spectrum image biochip detector of the present invention is a kind of slitless spectrum image biochip detector, and its general structure embodiment is as follows figure 1 As shown, it consists of four main components:

[0027] The line light source excitation unit is used to generate a line light source to excite a column of biochips to emit fluorescence. Its length is required to be greater than or equal to the length of a column of biochips 10 mm, and its width is required to be less than 50 μm per unit.

[0028] The slitless spectral imager is used to image the fluorescence emitted by a row of biochips according to the spectrum. The fluorescence emitted by each biochip unit is aligned by wavelength, resulting in a spectrum. The fluorescence of a row of units in the biochip forms a surface,...

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Abstract

The spectral image biological chip detection apparatus includes a line light source excitation unit capable of producing line light source for exciting biological chip to send fluorescent light; slitless spectral image apparatus for receiving fluorescent light sent by biological chip and forming spectral image; chip carrier and moving mechanism for bearing chip and moving under the control of the computer; and computer system for controlling movement of chip carrier, collecting spectral image signal, controlling exposure time, processing data and giving out judgement and detection result about disease and medicine. Said invention can promote the application of biological chip in diagnosis of diseases and medicine.

Description

technical field [0001] The invention belongs to the technical field of biochip detection, in particular to a detection device for biochips using spectral image technology. Background technique [0002] Biochips refer to protein biochips and DNA biochips. There have been many reports and publicity on the usefulness of biochips in diagnosing diseases. At present, it is a reality to diagnose many diseases from a drop of blood through biochips. In addition, the use of biochips in the inspection of sports doping is also a broad field. The development, production and application of biochips will bring about a revolution in the diagnosis of diseases and drugs, and this revolution will happen in the near future. Biochips will become an industry. At present, many units have invested a lot of manpower and material resources in the development and research of biochips. [0003] A biochip has many units: low-density biochips for medical and drug diagnosis, each unit has an area of ​...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01J3/443G01N21/64G01N33/50
Inventor 郭峻郭峰
Owner 蔡静军