Artificial tear

A technology of artificial tears and water-soluble chitin is applied in sensory diseases, drug combination and other directions, and achieves the effects of simple preparation method, good protection effect and good moisturizing property.

Inactive Publication Date: 2005-03-23
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of this invention is to provide a kind of artificial tear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0007] Example 1

[0008] Take 3.0 g of hydroxyethyl chitin, 0.2 g of quaternized chitosan, 5 g of sodium chloride, 0.4 g of calcium chloride, 3.4 g of potassium dihydrogen phosphate, and 3.7 g of disodium hydrogen phosphate, and dissolve it with 400 ml of water for injection. After filtering, the filtrate is diluted with water for injection to 1000ml, sterilized by circulating steam at 100°C, and then packed into a colorless, clear and slightly viscous artificial tear preparation. Dropping it into the eyes can replenish moisture, moisturize the surface of the eyes, produce a mucous, water-absorbent solution covering the surface of the eyes, eliminate eye discomfort, protect the eyes, and effectively relieve and treat dry eye.

[0009] The quaternized chitosan in this embodiment is made of hydroxypropyl chitosan or chitosan oligosaccharide (ChitosanOLigosaccharide, molecular weight ≤5000) in an alkaline isopropanol medium, with a molar ratio of 1:0.8-1.2 under stirring. Add alipha...

Example Embodiment

[0010] Example 2

[0011] Take 4g of hydroxypropyl chitosan, 0.1g of quaternized chitosan, 8g of sodium chloride, 0.2g of calcium chloride, 1.2g of potassium dihydrogen phosphate, and 4.3g of disodium hydrogen phosphate. Dissolve it with 400ml of water for injection. , Filter to remove insolubles, dilute the filtrate with water for injection to 1000ml, sterilize with circulating steam at 100°C, and then separate into artificial tear preparations, which also has the effect of the product of Example 1.

Example Embodiment

[0012] Example 3

[0013] Take chitosan oligosaccharide (molecular weight ≤5000) 5.0g, quaternized chitosan 0.3g, sodium chloride 6.0g, calcium chloride 0.6g, potassium dihydrogen phosphate 2.0g, disodium hydrogen phosphate 3.8g, first dissolved in 400-500ml water for injection, filtered, the filtrate was diluted with water for injection to 1000ml, sterilized by circulating steam at 100°C, and then packed into artificial tear preparation, which also has the effect of the product of Example 1.

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PUM

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Abstract

The artificial tear consists of water, water soluble chitin derivative, pH regulator, penetration pressure regulator and sterilizing agent in weight ratio of 1000 to 1-6 to 4-8 to 5-8 to 0.001-0.3. The present invention has the advantages of adoption of water soluble chitin derivative as main material, simple preparation process, good moisture absorbing and moisture maintaining performance, no chemical preservative contained, bacterostasis and bactericidal effect on many kinds of bacteria, relatively high viscosity at low concentration and shearing dilution; accords with the requirement on tear; and has excellent eye membrane protecting effect.

Description

technical field [0001] The present invention relates to an artificial tear. Background technique [0002] Artificial tears are similar in nature to the tears secreted by the human body. They can replenish water to the eyes, moisten the ocular surface, kill bacteria, protect the eyes, eliminate eye discomfort, treat dry eye, and relieve other eye diseases caused by eye diseases. . The main raw materials of commonly used artificial tears are sodium hyaluronate and polymer substances such as polyacrylic acid, polyvinyl alcohol, carboxymethyl cellulose, and hydroxypropyl methyl cellulose. Among them, the tears made of sodium hyaluronate have the best effect, but the cost is high, and the tears made of other materials have poor biocompatibility and damage the eye membrane. Contents of the invention [0003] The purpose of the present invention is to provide a kind of artificial tear, which can overcome the above-mentioned shortcoming of existing artificial tear. [0004] An ...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P27/04
Inventor 陈国华孙明昆
Owner OCEAN UNIV OF CHINA
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