Cetirizine hydrochloride gel

A technology of cetirizine hydrochloride and lizine gel, which is applied in the field of medicine to achieve the effects of prolonging the action time, reducing blood drug concentration, and good therapeutic effect

Inactive Publication Date: 2005-10-19
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with other antihistamines, although the central nervous system activity of cetirizine hydrochloride is lower, it still has adverse reactions such as drowsiness, dizziness, and headache when taken orally

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1 Preparation of cetirizine hydrochloride gel

[0010] Formula and ratio:

[0011] Carbopol 740 1g Menthol 8g

[0012] Cetirizine Hydrochloride 1g Propylene Glycol 10ml

[0013] Glycerin 5ml Triethanolamine 1.5g

[0014] Ethylparaben 0.1g distilled water to 100g

[0015] The preparation method is: fully swell Carbopol 740 with 40 times distilled water, add cetirizine hydrochloride, glycerin, menthol, propylene glycol, ethylparaben and triethanolamine respectively according to the above ratio, add distilled water to 100g, and stir Evenly, it becomes a gel. The finished gel contains 10 mg of cetirizine hydrochloride per gram.

Embodiment 2

[0016] Embodiment 2 Preparation of cetirizine hydrochloride gel

[0017] Formula and ratio:

[0018] Hypromellose 1.5g Azone 5ml

[0019] Cetirizine Hydrochloride 1g Propylene Glycol 15ml

[0020] Glycerin 10ml Ethylparaben 0.1g

[0021] Distilled water up to 100g

[0022] The preparation method is as follows: add hypromellose to 50 times of distilled water to fully swell, add cetirizine hydrochloride, glycerin, azone, propylene glycol, ethylparaben respectively according to the above ratio, add distilled water to 100g, stir evenly, Serve as a gel. The finished gel contains 10 mg of cetirizine hydrochloride per gram.

Embodiment 3

[0023] Embodiment 3 preparation cetirizine hydrochloride gel

[0024] Formula and ratio:

[0025] Polyvinylpyrrolidone 2g Ethylparaben 0.1g

[0026] Cetirizine Hydrochloride 1g Glycerin 8ml

[0027] Distilled water up to 100g

[0028] The preparation method is as follows: add polyvinylpyrrolidone to 50 times of distilled water to fully swell, add cetirizine hydrochloride, glycerin and ethylparaben respectively according to the above ratio, add distilled water to 100g, and stir evenly to form a gel. The finished gel contains 10 mg of cetirizine hydrochloride per gram.

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PUM

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Abstract

The present invention relates to the field of medicine technology and is one externally applied form of Cetirizine hydrochloride gel as one histamine resisting medicine and its preparation. The present invention prepares the gel with Cetirizine hydrochloride as main medicine component and different supplementary material, and the gel is administrated via skin or mucous membrane. The present invention can avoid liver reaction and stimulation to gstrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to an external dosage form of antihistamine cetirizine hydrochloride—a gel and a preparation method thereof. Background technique: [0002] Cetirizine hydrochloride is a second-generation antihistamine, which has a good therapeutic effect on allergic diseases of the skin, respiratory system and eyes, such as skin urticaria, allergic asthma, allergic rhinitis and allergic conjunctivitis. . At present, the pharmaceutical dosage forms of this medicine include conventional dosage forms such as tablets, capsules, and solutions, and the route of administration is all oral. Compared with other antihistamines, although the central nervous system activity of cetirizine hydrochloride is lower, the drug still has adverse reactions such as drowsiness, dizziness, and headache when taken orally. Invention content: [0003] The invention provides an external administration preparation of cetir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/495A61K47/32A61K47/38A61P37/08
Inventor 胡晋红刘继勇朱全刚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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