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Method for preparing ten nanometers level solid lipid nanometer particle

A solid lipid nanometer and nanometer technology, which is applied in the methods of granulating raw materials, liposome delivery, chemical instruments and methods, etc., can solve problems such as large size, achieve high repeatability, convenient transportation, storage and use, Simple and convenient preparation process

Inactive Publication Date: 2006-08-16
苏州纳康生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Implants and microparticles are too large for targeted drug delivery and intravenous administration

Method used

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  • Method for preparing ten nanometers level solid lipid nanometer particle

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preparation example Construction

[0023] The preparation method of ten nanometer order solid lipid nanoparticles of the present invention is:

[0024] a, weigh lipid material and emulsifier respectively, the mass ratio of the two, i.e. lipid material: emulsifier is 1: 4~1: 6; after mixing lipid material and emulsifier, heat to set temperature T, That is, T=60-80 degrees Celsius, and the liquid oil phase is obtained after melting; wherein, the lipid material is glyceryl monostearate, and the emulsifier is polyoxyl stearate S-40 and poloxamer F-68 according to 7:3 mixture,

[0025] b. Weigh the substance loaded by the lipid material as the carrier, the mass ratio of the substance to the lipid material is 1: 10 to 1: 200, add the substance into the liquid oil phase, stir to dissolve the substance completely, and obtain clarification system;

[0026] c. Add water at the same temperature as the set temperature T to the above-mentioned clarification system. The quality of the water is 20 to 200 times that of the l...

Embodiment 1

[0033] 1. Weigh 2.1 grams of polyoxyl stearate S-40, 0.9 grams of poloxamer F-68, and 0.5 grams of glyceryl monostearate, and put them into the sample tube;

[0034] 2. Heating in a water bath at 60°C to make it completely melted and then adding 20 mg of vitamin E to obtain a clarified system;

[0035] 3. Add 24 ml of distilled water at 60°C to the above clarification system;

[0036] 4. Stir for 10 minutes;

[0037] 5. Decrease to room temperature to obtain ten nanometer solid lipid nanoparticle dispersion.

[0038] 6. Freeze-drying to obtain vitamin E solid lipid nanoparticles of ten nanometer scale.

Embodiment 2

[0040] 1. Weigh 2.1 grams of polyoxyl stearate S-40, 0.9 grams of poloxamer F-68, and 0.5 grams of glyceryl monostearate, and put them into the sample tube;

[0041] Heating in a water bath at 2.75°C to make it completely melted and then adding 5 mg of azelaic acid to obtain a clarified system;

[0042] 3. Add 24 ml of distilled water at 75°C to the above clarification system;

[0043] 4. Stir for 20 minutes;

[0044] 5. Decrease to room temperature to obtain ten nanometer solid lipid nanoparticle dispersion.

[0045] 6. Freeze-drying to obtain ten nanometer-sized azelaic acid solid lipid nanoparticles.

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Abstract

The present invention is the preparation process of ten nanometer level solid lipoid particle as medicine carrier, cosmetic and other fine chemical material. The preparation process includes: a) mixing lipoid material and emulsifier in the weight ratio of 1 to 4-6 and heating the mixture to 60-80 deg.c to obtain liquid oil phase; b) adding the matter the lipoid material carries into the liquid phase with the ratio between the matter to the lipoid material being 1 / 200-1 / 10 and stirring for dissolving completely to obtain clear system; c) adding water in the weight of 20-200 times the lipoid material and at the temperature of 60-80 deg.c into the clear system and stirring mechanically for 5-60 min; d) cooling to room temperature and filtering to obtain the dispersed liquid of ten nanometer level solid lipoid particle; and e) freezing drying.

Description

technical field [0001] The invention relates to a preparation method of a nano medicine carrier and a fine chemical material carrier such as cosmetics, especially a preparation method of a ten-nano-level solid lipid nanoparticle. Background technique [0002] The combination of the drug and the carrier makes the in vivo process of the drug no longer only depend on the properties of the drug itself, but largely depends on the performance of the carrier system. Proper selection of the carrier system enables the controllable and localized release of the active drug according to the special needs of drug therapy. Carriers can be divided into nanocarriers, micron-sized particles and millimeter-sized implantable carriers according to their size. Implants and microparticles are too large for targeted drug delivery and intravenous injection. Therefore, nano-drug carriers have received extensive attention from researchers in recent years. [0003] Current...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K9/20A61K47/24B01J2/00A61K9/127
Inventor 夏强顾宁陆杨燕夏勇
Owner 苏州纳康生物科技有限公司
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