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Polymer microsphere encoded by nano-gold and method for preparing same

A technology of polymer and gold nanoparticles, applied in the field of polymer microspheres, can solve the problems of high production equipment requirements, uneven particle size and high production cost, and achieve the effects of reducing application cost, simple preparation device and low cost

Inactive Publication Date: 2006-10-18
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used polymer microsphere preparation methods include emulsion polymerization, dispersion polymerization, seed polymerization, suspension polymerization and microsuspension polymerization, etc., but the particle size of microspheres prepared by this method is in the nanometer and submicron range, and will Difficulty encapsulating certain particles in polymers
The methods for preparing polymer microspheres with a particle size of several hundred microns to several millimeters include spray drying method and template method, but there are problems such as uneven particle size, high requirements for production equipment, and high production cost.

Method used

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  • Polymer microsphere encoded by nano-gold and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of green pearlescent pigment-encoded carboxyl-modified polystyrene microspheres

[0027] ①Dissolve the carboxyl-modified polystyrene solid in a mixed solvent of dichloroethane and benzene at a concentration of 7g / 100ml, and the mixing ratio of dichloroethane and benzene is 1:1;

[0028] ② Add red gold nanoparticles to the polystyrene solution at a ratio of 0.1 mg nano-gold particles / ml polymer solution, and stir evenly;

[0029] ③The diameter of the tip of the tip glass tube 4 is set to 200 μm, and the distance between the upper port of the glass conduit 5 and the tip of the tip glass tube is 1 mm;

[0030] ④ Inject 5% polyvinyl alcohol solution into the glass cylinder through the interface 2 of the electromagnetic pump. When the glass cylinder 3 is filled with the polyvinyl alcohol solution, control the injection speed of the polyvinyl alcohol solution to 25ml / min;

[0031] ⑤Inject the polystyrene solution containing green pearlescent pigment th...

Embodiment 2

[0034] Example 2: Preparation of purple pearlescent pigment-coded polymethyl methacrylate microspheres

[0035]① Dissolve polymethyl methacrylate in a mixed solvent of dichloroethane and benzene at a concentration of 5g / 100ml, and the mixing ratio of dichloroethane and benzene is 2:3;

[0036] ②Add green pearlescent pigment to the polystyrene solution at a ratio of 0.5mg pearlescent pigment / ml polymer solution, and stir evenly;

[0037] ③Set the diameter of the tip of the tip glass tube 4 to be 200 μm, and the distance between the upper port of the glass conduit 5 and the tip of the tip glass tube is 1.5 mm;

[0038] ④Inject 5% polyvinyl alcohol solution into the glass cylinder through the interface 2 of the electromagnetic pump. When the glass cylinder (3) is filled with polyvinyl alcohol solution, control the injection speed of the polyvinyl alcohol solution to 20ml / min;

[0039] ⑤Inject the polystyrene solution containing purple pearlescent pigment through the syringe pump...

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Abstract

A polymer microsphere encoded by nano-gold particles and a preparation method thereof, relating to a polymer microsphere that can be used as a high-throughput carrier for multiple biological analysis and protein, gene, and drug screening. The microsphere is composed of ethylene polymer and Nano-gold particles, wherein: the content of nano-gold particles in polymer microspheres is 1.42-33.3‰, and the ethylene polymer is polystyrene, or polymethyl methacrylate, or polyacrylonitrile, or polyethylene, or poly Acrylic, or polyethyl acrylate. The preparation method comprises the following steps: dissolving ethylene polymer in an organic solvent to form an ethylene polymer solution, dropping the ethylene polymer solution into a polyvinyl alcohol solution through a droplet generating device, and obtaining polymer microspheres after the organic solvent is volatilized.

Description

technical field [0001] The invention relates to a polymer microsphere that can be used as a high-throughput carrier for multiple biological analysis and protein, gene, and drug screening, in particular to a polymer microsphere encoded by nano gold and a preparation method thereof. Background technique [0002] After the human genome sequence was decoded, the function of the gene and the interaction between the proteins encoded by the gene became a research hotspot, and human beings entered the post-genome era. A notable feature of the post-genome era is to study a large number of interactions between proteins and nucleic acids, proteins and proteins, and proteins and drugs. The study of these interactions is almost impossible with traditional experimental methods. Therefore, a high-throughput test platform is needed. The high-throughput test platform requires a high-throughput molecular carrier to identify the different interactions of different molecules, which is the so-c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L25/06C08L33/12C08K3/08
Inventor 顾忠泽赵祥伟
Owner SOUTHEAST UNIV
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