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Injection liquid in use for intravenous injection and preparation method

A technology of injection and preparation process, which is applied to pneumonia, can solve the problems of affecting the efficacy of medicines, ignoring wogonoside, and low content of active ingredients, and achieve the effects of facilitating the preparation of modern preparations, improving the efficacy of medicines, and increasing stability

Active Publication Date: 2006-11-01
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yes, they use the same conventional extraction and refining methods as other Yinhuang injections: the extraction of honeysuckle takes chlorogenic acid as an index and ignores the effect of active ingredients such as isochlorogenic acid, and the content of chlorogenic acid is too low, a large number of impurities and ineffective ingredients It poses a great threat to the safety and stability of the drug; the extraction process of Scutellaria baicalensis is based on baicalin, although some of them have high purity, but ignore the effect of active ingredients such as wogonin, which affects the curative effect of the drug
Conventional preparations use extracts as medicines, respectively using chlorogenic acid and baicalin as indicators, the content of active ingredients is low, and the ingredients in the extracts are not clear, leaving hidden dangers to the safety and stability of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0284] Chlorogenic acid 0.1g

[0285] Baicalin 1g

[0286] Water for injection (add to) 1000ml

[0287] Put the amount of chlorogenic acid and baicalin into an appropriate amount of water, use 1mol / L sodium hydroxide to adjust the pH value of the liquid medicine, make the pH value of the liquid medicine be in the range of 6.0-6.8, and dissolve under stirring. Add water for injection to make it 1000ml, and use 1mol / L sodium hydroxide or hydrochloric acid to adjust the pH value of the medicinal solution to 5.0. Determine the content and pH value of the semi-finished product according to the quality standard of the semi-finished product. Start potting and measure the filling volume regularly. Sterilize at 100°C for 30 minutes, leak detection, light inspection, packaging, and storage.

Embodiment 2

[0289] Chlorogenic Acid 25g

[0290] Baicalin 40g

[0291] Water for injection (add to) 1000ml

[0292] Chlorogenic acid and baicalin are put into an appropriate amount of water, and 1mol / L sodium hydroxide is used to adjust the pH value of the medicinal solution so that the pH value of the medicinal solution is within the range of 6.0 to 6.8, and dissolved under stirring. Add activated carbon with 1% liquid medicine amount, raise the temperature to 70°C, and stir for 30 minutes. Use a sand filter rod and a vacuum pump to filter the liquid medicine. Add water for injection to make it 1000ml, and use 1mol / L sodium hydroxide or hydrochloric acid to adjust the pH value of the medicinal solution to 8.0. Use a filter to filter the liquid medicine, and measure the content and pH value of the semi-finished product according to the quality standard of the semi-finished product. Start potting and measure the filling volume regularly. Sterilize at 100°C for 30 minutes, leak detecti...

Embodiment 3

[0294] Chlorogenic acid 0.1g

[0295] Baicalin 40g

[0296] Water for injection (add to) 1000ml

[0297] Add the amount of chlorogenic acid and baicalin into it, use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, make the pH value of the medicinal solution within the range of 6.0-6.8, stir and dissolve. Add water for injection to make to 1000ml, and use 1mol / L sodium hydroxide or hydrochloric acid to adjust the pH value of the medicinal solution to 7.0. Use a filter to filter the liquid medicine, and measure the content and pH value of the semi-finished product according to the quality standard of the semi-finished product. Start potting and measure the filling volume regularly. Sterilize at 100°C for 30 minutes, leak detection, light inspection, packaging, and storage.

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PUM

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Abstract

The invention discloses an injection for intravenous injection and a preparation method thereof. The main active ingredients of the medicine are chlorogenic acid 0.1-25 mg / ml, baicalin 1-40 mg / ml, and does not contain forsythin and geniposide. This medicine has remarkable curative effect on upper respiratory tract infection, pneumonia and respiratory virus infection.

Description

technical field [0001] The invention relates to an injection for treating upper respiratory infection and pneumonia and resisting upper respiratory virus. [0002] Specifically, it is an injection prepared from Chinese herbal medicine, and also relates to a preparation method of the medicine. Background technique [0003] In my country, upper respiratory tract infections such as pharyngitis and tracheitis, pneumonia and respiratory virus infection are common and frequently-occurring diseases. Not only itself often protracted, but also can cause a variety of complications, endangering human health. With the development of industrial society, the air is polluted to varying degrees, which increases the incidence of upper respiratory tract infections and pneumonia-like diseases such as rhinitis and pharyngitis. Modern medicine believes that although the main pathogenic bacteria of this disease are streptococci, mixed infections of bacteria and viruses are not uncommon, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61K36/35A61K9/08A61P11/00C07C69/732C07H17/07
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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