Combination of medication for treating gallbladder disease and preparation method

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for the treatment of gallbladder disease and its preparation, can solve the problems of affecting the curative effect, simply clearing away heat and removing dampness, treating the symptoms but not the root cause, and achieving good curative effect

Active Publication Date: 2006-11-01
NANJING TONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, for patients with cholelithiasis, due to liver and gallbladder damp-heat stagnation for a long time, long-term use of heat-clearing and damp-dispelling drugs will consume righteousness, and easily damage the spleen and stomach, resulting in spleen-stomach qi deficiency, which may make it more difficult to cure damp-heat, or affect the stability of the curative effect
Therefore, simply clearing away heat and removing dampness will treat the symptoms but not the root cause

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Phase II clinical research

[0032] Phase II clinical research approval number of the pharmaceutical composition of the present invention for the treatment of cholelithiasis complicated by chronic cholecystitis with damp-heat and qi-blood stasis syndrome: State Drug Administration No. 2001ZL250

[0033] Test center: Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, West China Hospital of Sichuan University (First Affiliated Hospital of West China University of Medical Sciences), Affiliated Hospital of Shaanxi Academy of Traditional Chinese Medicine

[0034] Purpose of the test: To evaluate the efficacy and safety of the pharmaceutical composition granules of the present invention in treating cholelithiasis complicated with chronic cholecystitis with damp-heat and qi-blood stasis syndrome

[0035] Experimental design: stratified block randomized, parallel controlled, do...

Embodiment 2

[0071] The raw medicinal materials used in the pharmaceutical composition of the present invention are all pharmacopoeia varieties, and all are commercially available decoction pieces.

[0072] Prescription: Desmodium 5 grams, Gardenia 2.5 grams, Phellodendron 1.7 grams, Cassia 2 grams, Rhizoma Chuanxiong 1.7 grams, Magnolia officinalis 2 grams, Cortex Moutan 1.7 grams, Sun-dried ginseng 1 gram, Guizhi 1.7 grams, Capillaris 2.5 grams, 1 gram of rhubarb, 1.7 grams of French pinellia, 2.5 grams of hawthorn, 1.7 grams of peach kernel, 1 gram of safflower, 2.5 grams of Cyperus cypress, 1.7 grams of citrus aurantium, and 1.7 grams of woody fragrance.

[0073] 1. Take the prescribed amount of magnolia officinalis, rhubarb, cassia seed, raw sun-dried ginseng, and Pinellia five flavors and grind them into coarse powder, use 60% ethanol as solvent, soak for 24 hours, percolate, collect 6 times the amount at a collection speed of 3ml / min (Based on the weight of medicinal materials), rec...

Embodiment 3

[0079] Prescription: 5 grams of Desmodium, 2.5 grams of Gardenia, 1.5 grams of Cortex Phellodendri, 2 grams of Semen Cassiae, 1.5 grams of Chuanxiong, 2 grams of Magnolia officinalis, 1.5 grams of Moutan Cortex, 1 gram of Sun-dried Ginseng, and 1.5 grams of Guizhi.

[0080] 1. Extract the Semen Cassiae, Magnolia Magnolia officinalis, and Sun-dried Ginseng containing 80% ethanol as a solvent, and after concentration, obtain an extract of the alcohol extract, with a relative density of about 1.10 (50° C.);

[0081] 2. Steam distill the Cortex Moutan of the described weight ratio, collect 7 times the amount (by medicinal material weight) distillate, refrigerate overnight, filter to obtain paeonol crystals; paeonol crystals add appropriate amount of ethanol after dissolving , use β-CD for inclusion, dry the inclusion, and pulverize into fine powder to obtain inclusion A, which is set aside.

[0082] 3. Extract the volatile oil from the cassia twigs, chuanxiong and Desmodium in the...

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PUM

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Abstract

A medicinal composition for the treatment of gallbladder disease is mainly made of Radix chinensis, gardenia, Phellodendron chinensis, cassia seed, and Chuanxiong, and can be added with Magnolia officinalis, Cortex Moutan, ginseng, cassia twig, etc., and the prepared oral preparation can clear away heat. Dampness is the main treatment, supplemented by activating qi to relieve depression, promoting blood circulation and removing blood stasis, and at the same time invigorating qi and strengthening the righteousness, it can prevent the long-term use of heat-clearing and damp-damping drugs from depleting the righteous qi.

Description

technical field [0001] The invention belongs to a pharmaceutical composition for treating gallbladder disease derived from traditional Chinese medicine and a preparation method thereof, in particular to a pharmaceutical composition for treating cholelithiasis and / or cholecystitis and an industrially applicable preparation method thereof. Background technique [0002] Cholelithiasis is characterized by right upper quadrant pain, right shoulder pain, bitter mouth and constipation, or yellow body and eyes as the main clinical manifestations. Chinese medicine believes that the gallbladder is attached to the liver and is the organ of the middle essence. Bile is "formed by borrowing the remaining qi from the liver, overflowing into the gallbladder and accumulating". Emotional disorders, stagnation of liver qi, or stagnation of qi for a long time, stagnation of qi and blood stasis; improper diet, excessive fat and sweetness, dysfunction of the spleen, internal stagnation of dampne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61K36/8888A61K36/756A61K9/20A61P1/16
Inventor 陈家进刘俊怡
Owner NANJING TONGRENTANG PHARM CO LTD
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