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Pyrithioxine hydrochloride freeze-dried composition and its preparing method

A technology of pyrithione hydrochloride and freeze-dried powder injection, which is applied in the field of medicine, can solve the problems of poor solubility, inconvenient use, and poor bioavailability of pyrithione hydrochloride, and achieve poor bioavailability and improve solubility and stability , to ensure the effect of safety and convenience

Inactive Publication Date: 2006-11-22
ZHEJIANG JIANFENG PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor solubility of pyrithione hydrochloride in its oral preparations, there has always been a problem of poor bioavailability, and its sterile subpackaged powder for injection is also limited in clinical use due to its poor solubility. very inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: Get pyrithione hydrochloride 400g, and mannitol 200g, make 1000 bottles. Add pyrithione hydrochloride and mannitol into the batching barrel, add boiled water for injection cooled to 80°C, fully dissolve to make it a uniform solution; add activated carbon and stir, let stand, filter, freeze-dry, seal to obtain white hydrochloric acid Pyritinol freeze-dried powder injection. Parameter control during freeze-drying: the pre-freezing temperature is -40°C, and the pre-freezing time is 4 hours; the sublimation drying temperature is -30°C, and the sublimation drying time is 30 hours.

Embodiment 2

[0015] Embodiment 2: Get pyrithione hydrochloride 100g, and lactose 200g, make 1000 bottles. Add pyrithione hydrochloride and lactose into the ingredients barrel, add boiled water for injection cooled to 80°C, fully dissolve to make it a uniform solution; add activated carbon and stir, let stand, filter, freeze-dry, and seal to obtain white pyrithione hydrochloride Thiol freeze-dried powder injection. Parameter control during freeze-drying is optimized: the pre-freezing temperature is -30°C, and the pre-freezing time is 5 hours; the sublimation drying temperature is -10°C, and the sublimation drying time is 25 hours.

Embodiment 3

[0016] Embodiment 3: Get pyrithione hydrochloride 200g, and mannitol 100g, lactose 100g, make 1000 bottles. Add pyrithione hydrochloride, mannitol, and lactose into the batching barrel, add water for injection that has been boiled and cooled to 80°C, fully dissolve to make it a uniform solution; add activated carbon and stir, let stand, filter, freeze-dry, and seal to obtain White pyrithione hydrochloride freeze-dried powder injection. Parameter control during freeze-drying is optimized: the pre-freezing temperature is -40°C, and the pre-freezing time is 4.5 hours; the sublimation drying temperature is -15°C, and the sublimation drying time is 28 hours.

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PUM

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Abstract

The invention relates to the technical field of medicine, in particular to a pyrithione hydrochloride freeze-dried powder injection and a preparation method thereof, a pyrithione hydrochloride freeze-dried powder injection, comprising pyrithione hydrochloride and auxiliary materials, and the weight ratio of pyrithione hydrochloride and auxiliary materials It is 1:0.2~2, the auxiliary materials include excipients, put pyrithione hydrochloride and auxiliary materials into the batching barrel, then add water for injection, fully dissolve, add activated carbon and stir, let stand, filter, and then put the filtered solution into Put it into a freeze dryer for freeze-drying, and seal it after the freeze-drying is completed. The freeze-dried powder injection of pyrithione hydrochloride of the present invention solves the problem of poor water solubility of pyrithione in the prior art, adopts freeze-drying technology, and adds The excipient improves the solubility of pyrithione and solves the problem of poor bioavailability of pyrithione.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pyrithione hydrochloride freeze-dried powder injection and a preparation method thereof. Background technique [0002] Pyritinol hydrochloride (molecular formula: C 16 h 20 N 2 o 4 S 2 ·2HCl·H 2 O) is a drug that improves brain metabolism and is a vitamin B 6 Derivatives of it can promote glucose and amino acid metabolism in the brain, improve systemic assimilation, increase carotid blood flow, and enhance brain function. It also has a stimulating effect on the limbic system and reticular structure. Pyritinol hydrochloride is mainly suitable for dizziness pain, insomnia, memory loss, lack of concentration, improvement of emotional changes in sequelae of brain trauma, encephalitis and meningitis sequelae; it can also be used for cerebral arteriosclerosis and senile dementia mental symptoms . [0003] Pyritinol hydrochloride is widely used clinicall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4415A61K9/19A61P25/20A61P25/00
Inventor 金三九张健楼金芳
Owner ZHEJIANG JIANFENG PHARM CO LTD