Germanium caffeiate and its preparation technology
A caffeic acid, inhibitory technology, applied in germanium organic compounds, drug combinations, anti-tumor drugs, etc., can solve the problems of large side effects, strong toxicity, unsuitable for clinical use, etc., and achieves improved biological activity, reduced toxicity, and good water solubility. Effect
Inactive Publication Date: 2007-01-24
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
In 1984, Soviet scholars reported the anti-tumor active substance-Xumochuangermanium compounds. In 1994, Nankai University reported the trihydrocarbyl tin-based Umochuangermanium. Some of the above compounds have fatal defects of strong toxicity and large side effects, so they are not suitable for use. in clinical
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[0017] The best embodiment of this invention is: prepare with germanium dioxide and sodium hypophosphite, trichlorogermanium form, then make 3-trichlorogermanium-3-(3,4) with 3,4-dihydroxybenzoic acid -dihydroxyphenyl)propionic acid, and finally react with sodium methoxide, ethanol and triethanolamine to obtain germanium caffeate.
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Abstract
A germanium dihydroxycinnamate with high antineoplastic activity is prepared through synthesizing trichlorogermform from GeO2 and sodium phosphite, synthesizing 3-trichlorogerm-3-(3,4-dihydroxy benzene) acrylate from trichlorogermform and 3,4-dihydroxy benzene acrylate, and adding methanol sodium, ethanol and triethanolamine. Its advantages are high activity, low poison and high water solubility.
Description
technical field [0001] The invention relates to the technical field of chemically synthesized drugs and synthesis techniques, in particular to germanium caffeate for human use and a preparation technique thereof. Background technique [0002] Tumor is a difficult problem to be solved urgently by the medical circle in the world at present. The anti-cancer chemotherapeutic drugs currently used have high toxicity and side effects, which often lead to the termination of chemotherapy for some patients, resulting in aggravation of the condition. How to find new anti-tumor drugs with higher curative effect and lower toxicity is an urgent need for people, and it is also a need for clinical medicine. The present invention modifies some existing proven anti-tumor compounds, adds some active groups on the basis of the original structure, and transforms and removes some highly toxic groups. Mining chemical anticancer drugs is an important direction and way to f...
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IPC IPC(8): C07F7/30A61K31/555A61P35/00
Inventor 陈晓东肖纯毕树平
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE