Preparation technology of germanium caffeate
A preparation process and process technology, applied in the field of germanium caffeate for human use and its preparation process, can solve the problems of strong toxicity, unsuitable for clinical use, and large side effects, and achieve the effects of increased biological activity, good water solubility, and reduced toxicity
Inactive Publication Date: 2016-04-20
刘振宇
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Problems solved by technology
In 1984, the Soviet scholars reported the first-order manganese-type compounds with anti-tumor activity, and in 1994, Nankai University reported the trihydrocarbyl tin-like manganese-germanium compounds. Some of the above-mentioned compounds have fatal defects of strong toxicity and large side effects, so they are not suitable for use. in clinical
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Embodiment Construction
[0011] The best embodiment of this invention is: prepare with germanium dioxide and sodium hypophosphite, trichlorogermanium form, then make 3-trichlorogermanium-3-(3,4) with 3,4-dihydroxybenzoic acid -dihydroxyphenyl)propionic acid, and finally react with sodium methoxide, ethanol and triethanolamine to obtain germanium caffeate.
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Abstract
The invention relates to a drug, which has a prominent effect on human and takes germanium caffeate as the basic active component, and a preparation technology thereof. The preparation method comprises the following steps: using germanium dioxide and sodium phosphite to synthesize germanium chloroform, then reacting germanium chloroform with 3,4-dihydroxylphenyl acrylic acid to generate 3-trichlorogermyl-3-(3,4-dihydroxylphenyl)acrylic acid, and finally adding sodium methanol, ethanol, and triethanolamine into 3-trichlorogermyl-3-(3,4-dihydroxylphenyl)acrylic acid to obtain germanium caffeate. The drug has the advantages of simple technology, low cost, suitability for industrial production, strong activity, low toxicity, good water solubility, and strong antitumor effect, and is a good drug in clinic.
Description
technical field [0001] The invention relates to the technical field of chemically synthesized drugs and synthesis techniques, in particular to germanium caffeate for human use and a preparation technique thereof. Background technique [0002] Tumor is a difficult problem to be solved urgently by the medical circle in the world at present. The anti-cancer chemotherapeutic drugs currently used have high toxicity and side effects, which often lead to the termination of chemotherapy for some patients, resulting in aggravation of the condition. How to find new anti-tumor drugs with higher curative effect and lower toxicity is an urgent need for people, and it is also a need for clinical medicine. The present invention modifies some existing proven anti-tumor compounds, adds some active groups on the basis of the original structure, and transforms and removes some highly toxic groups. Mining chemical anticancer drugs is an important direction and way to find new anticancer drugs...
Claims
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IPC IPC(8): C07F7/30A61P35/00
Inventor 刘振宇
Owner 刘振宇