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Compsns. for increasing energy i(in vivo)

A composition and energy level technology, applied in the directions of drug combination, carbohydrate active ingredients, medical preparations containing active ingredients, etc., can solve the problem of inability to eliminate the de novo synthesis of contractile muscles and other problems

Inactive Publication Date: 2001-08-01
BIOENERGY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They further disclose that addition of ribose to the perfusate increases de novo synthesis of AMP in sedentary muscles in rat hind leg specimens, but fails to abolish the decrease in de novo synthesis in contracted muscles

Method used

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  • Compsns. for increasing energy i(in vivo)
  • Compsns. for increasing energy i(in vivo)
  • Compsns. for increasing energy i(in vivo)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Effect of D-ribose on Nucleotide Salvage in Resting Rat Muscle

[0039] It has been shown theoretically, but not objectively, that ribose synthesis via PRPP increases the rate of ATP synthesis via the nucleotide salvage pathway. However, nothing is known about total adenine nucleotide (TAN) or ribose levels in resting muscle. It is therefore possible that this synthetase pathway has been saturated and ribose administration fails to increase ATP levels in normal, non-ischemic skeletal muscle. To demonstrate the effect of ribose on this pathway, healthy adult male Sprague-Dawley rat plantar complex muscles were surgically exposed and perfused with reconstituted blood infusion medium containing amino acids, mM glucose, and 100 μU bovine insulin / ml. Muscles are perfused with reconstituted blood medium at approximately 40 ml / min, providing tissue perfusion of approximately 0.65 ml / min. Different concentrations of D-ribose were added to the perfusate to achieve a ...

Embodiment 4

[0060] Administration of D-ribose immediately before and during activity enhanced the beneficial effects in those subjects who did not exercise. As described in Example 2 above, the full-speed running output power of 4 healthy, normal male volunteers in the discharge cycle was tested. Each experimenter served as its own control. Between bouts of full-speed running, the subject should perform slow and continuous loops. The total test time was 1 hour with 4 full speed running bouts during the test. After the initial baseline measurement and after each full-speed running bout, the subject is administered 5 g of D-ribose or a similarly flavored placebo (glucose) in 200 ml. Full speed running power output was measured 15 minutes after ingestion of the test solution. Each subject underwent two periods, one of ribose and one of placebo, in random order, with one week in between. The placebo was sweetened with dextrose so as to be indistinguishable from the ribose solution. The s...

Embodiment 5

[0062] As the colic worsened, the patient could only walk less than 1 mile per day and had to take sublingual nitroglycerin when he got there. The patient was orally administered D-ribose dissolved in about 250 cc of water. The patient received intermittent doses of 5-10 g of D-ribose per day for 6 months. Following ribose administration, the patient was able to improve his daily exercise tolerance up to 2 miles without any supplemental oral nitrate administration. When ribose is interrupted, and its recurrence of exercise-induced angina prior to ribose administration occurs, supplemental oral nitroglycerin must be used. Reintroduction of oral ribose allowed the patient to walk 2 miles per day without developing angina or requiring nitroglycerin. His subjective evaluation of ribose treatment was "very weak angina, I feel better, have more energy and can do more activities without pain or medication (nitroglycerin)". Embodiment 5 is to the improvement of treadmill test behav...

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PUM

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Abstract

The invention discloses precursors of adenosine triphosphate are administered orally to increase intracellular ATP concentration as dietary supplements or for treatment of reduced energy availability resulting from strenuous physical activity, illness or trauma. Pentose sugars are administered individually, mixed into dry food or in solution. The preferred pentose is D-ribose, singly or combined with creatine, pyruvate, L-carnitine and / or vasodilating agents. Additionally, magnesium, electrolytes, fatty acids and hexose sugars can be used. The compositions and methods of this invention are especially beneficial to mammals having reduced energy availability or high energy demand.

Description

field of invention [0001] The present invention relates to compositions and methods effective for increasing energy in mammals with low energy availability or high levels of energy expenditure. Such mammals include humans suffering from diseases caused by decreased intracellular adenosine triphosphate (ATP), people engaged in heavy physical activity such as athletes or manual workers, and humans wishing to increase their energy levels. Other mammals such as dogs and cats are also included in the methods of the invention. Administration of the composition of the present invention can increase blood and intracellular ATP levels, prolong the time and intensity of mammalian activities, and improve the utilization rate of oxygen for exercisers. Non-exercising mammals and those mammals expending higher than normal levels of energy during recovery from physical injury such as trauma, burns and sepsis also benefit from the administration of the compositions of the present invention. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K33/06A61P3/00A61P43/00
CPCA61K33/06A61K31/198A61K31/197A61K31/7004A61P21/06A61P3/00A61P43/00A61P9/04A61K31/195A61K31/205A61K2300/00
Inventor J·圣西尔C·A·约翰逊
Owner BIOENERGY INC
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