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Effective site extract of lotus plumule and its usage

A technology of effective parts and extraction methods, applied in the field of extraction of effective parts of lotus seed heart, can solve problems that have not yet been seen, and achieve the effects of regulating insulin sensitivity, reducing the number of islet cells, and increasing the number of islet cells

Active Publication Date: 2007-05-09
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there have been no reports on the effective parts of the total alkaloids of lotus seed heart for the preparation of anti-diabetes and blood sugar-lowering drugs.

Method used

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  • Effective site extract of lotus plumule and its usage
  • Effective site extract of lotus plumule and its usage
  • Effective site extract of lotus plumule and its usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1. A method for extracting effective parts of lotus seed heart, the steps are as follows,

[0036] (1) taking the lotus seed heart and extracting it with 60% ethanol under reflux, merging the ethanol extract, and concentrating under reduced pressure;

[0037] (2) After concentrating the extract, add hydrochloric acid to adjust the pH to 4, and centrifuge to obtain the supernatant;

[0038] (3) adding ammonia water to the supernatant to adjust the pH to 9, then adding 10% sodium chloride, cooling at a low temperature below 10 degrees Celsius, and centrifuging to obtain a precipitate;

[0039] (4) The precipitate is dried under reduced pressure and crushed to obtain the extract of the effective part of the lotus seed heart.

Embodiment 2

[0040] Example 2. A method for extracting effective parts of lotus seed heart, the steps are as follows,

[0041] (1) take the lotus seed heart medicinal material and extract it by percolating with 70% ethanol, combine the ethanol extract, and concentrate under reduced pressure;

[0042] (2) After concentrating the extract, add sulfuric acid to adjust the pH to 4.5, and centrifuge to obtain the supernatant;

[0043] (3) Add milk of lime to the supernatant to adjust the pH to 9.5, then add 15% ammonium chloride, cool at a low temperature below 10 degrees Celsius, and centrifuge to obtain a precipitate;

[0044] (4) The precipitate is dried under reduced pressure and crushed to obtain the extract of the effective part of the lotus seed heart.

Embodiment 3

[0045] Example 3. A method for extracting effective parts of lotus seed heart, the steps are as follows,

[0046] (1) taking the lotus seed heart medical material and using concentration to be 80% ethanol impregnation extraction, merging the ethanol extract, concentrating under reduced pressure;

[0047] (2) After concentrating the extract, add citric acid to adjust the pH to 5, and centrifuge to obtain the supernatant;

[0048] (3) Add milk of lime to the supernatant to adjust the pH to 10, then add 20% ammonium chloride, cool at a low temperature below 10 degrees Celsius, and centrifuge to obtain a precipitate;

[0049] (4) The precipitate is dried under reduced pressure and crushed to obtain the extract of the effective part of the lotus seed heart.

[0050] It can be used to prepare medicines for preventing and treating syndrome X with insulin resistance IR as the basic pathology.

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Abstract

The invention relates to the extract from effective portion of lotus plumule which is prepared through the steps of , extracting medicinal material lotus plumule with alcohol, depression concentrating the raffinate to a finite density, charging in acids to adjust pH, centrifuging, alkalizing the supernatant fluid to adjust pH, charging in a definite quantity of sodium chloride or ammonium chloride, depositing for a finite period of time at low-temperature and centrifuging, obtaining deposition, decompressing and drying.

Description

technical field [0001] The invention relates to a method for extracting effective parts from Chinese herbal medicines, in particular to a method for extracting effective parts of lotus seed heart. Background technique [0002] Syndrome X is a group of clinical and laboratory syndromes with insulin resistance (IR) as the basic pathology, also known as IR syndrome or metabolic syndrome. Insulin (INS) blood, high blood pressure and IR are its characteristics. Insulin resistance (IR) refers to a series of pathophysiological changes caused by the decrease, damage or loss of the responsiveness of target tissues and organs to insulin, leading to metabolic disorders such as glucose and lipids. With the results of epidemiological investigations, evidence from experimental studies, and further understanding of the role of insulin, it is now clear that it is not only an important factor and a significant feature of type 2 diabetes, but also obesity, hypertension,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/472A61K36/62A61P3/10A61K131/00
Inventor 潘扬蔡宝昌李泽友曹亮张弦
Owner JIANGSU KANION PHARMA CO LTD