Nicergoline drip pill and its preparing method

Abstract

A dripping pill of nicergoline for treating cerebral arteriosclerosis, sequelae of cerebral apoplexy, vascular dementia, etc is prepared from nicergolina and medicinal carrier.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition with α-receptor blocking effect and vasodilator effect, used to improve cerebral arteriosclerosis and stroke sequelae caused by low intention and emotional disorders, and used to treat vascular dementia, in particular to A pharmaceutical composition oral preparation prepared from Nicergoline as a raw material. Background technique [0002] Nicergoline is a vasodilator with alpha-receptor blocking effect. It is often used to improve cerebral arteriosclerosis and stroke sequelae caused by low intentions and emotional disorders (such as: slow response, poor concentration, Memory loss, lack of thoughts, depression, restlessness), or for the treatment of acute and chronic peripheral circulatory disorders (such as: limb vascular occlusive disease, Raynaud’s syndrome, other peripheral circulatory symptoms), and can be used for the treatment of vascular dementia , Especially in the early treatment, it ca...

AI Technical Summary

Problems solved by technology

Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

[0009] Although the injection has the advantages of fast onset of action and high bioavailability, its production process is complicated, the cost is higher, and it is also accompanied by inconvenient use, prone to toxicity, side effects, and great pain for patients. Looking for a more suitable oral preparation of nicergoline to meet the health needs of the majority of patients