Medicine and health-care product formed from ganglioside and ginkgo leaf extract and their application

A technology of gangliosides and health products, which is applied in the field of drugs and health products for the treatment of nervous system diseases, and can solve problems such as single effect

Inactive Publication Date: 2002-03-27
上海脑力键生物医学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] One of the technical problems to be solved in the present invention is to provide a drug and health care product formulated with gangliosides and ginkgo leaf extract, to overcome the single d

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0200] Using ganglioside-containing animal organ extracts as the main raw material (provided by Baozhi Biological Products Co., Ltd.), preserved at -18°C; Ginkgo biloba extraction process: crush ginkgo biloba leaves, use 70% (v / v) ethanol 5 times and 4 times the amount is heated and refluxed for 2 hours. After recovering the ethanol, adjust the appropriate ratio, add 7% of 2% chitin flocculant, filter, and filter the filtrate on the DM130 macroporous adsorption column, gradient elution, and the eluate is concentrated separately , Dry and set aside. The content of gangliosides in raw materials containing gangliosides was determined by the resorcinol method provided by Shanghai Food Supervision and Inspection Institute; the content of active ingredients in Ginkgo biloba extract was determined by HPLC method.

Embodiment 2

[0202] The ganglioside and ginkgo biloba extract of Example 1 were prepared into capsules according to methods well known to those skilled in the art, using starch as a filler and 8% starch slurry as a binder to make granules and then encapsulating them. The specifications of the capsules are 100 mg / capsule. Among them, the content of ganglioside is 2mg / capsule, and the content of Ginkgo biloba extract is 30mg / capsule.

[0203] Raw materials containing ganglioside: 2 grams

[0204] Ginkgo biloba extract raw materials: 30 grams

[0205] Starch: 60 grams

[0206] 8% starch slurry: 8 grams

Embodiment 3

[0208] The ganglioside and ginkgo biloba extract of Example 1 were prepared into an oral liquid according to a method well known to those skilled in the art, and the oral liquid was prepared with citric acid and mannose as additives. The specification of the prepared oral liquid is 10ml / bottle. Among them, the content of ganglioside is 2mg / branch, and the content of Ginkgo biloba extract is 30mg / branch. Liquid raw materials containing gangliosides: 2 grams Purified water: 10 liters of Ginkgo biloba extract raw materials: 30 grams Mannose: 5 grams Citric acid: 10 grams.

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PUM

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Abstract

The present invention relates to a medicine formed from ganglioside and ginkgo leaf extract and its healht-care product and application. The animal experiments and clinical trials show that the medicine and health-care product possess good synergistic action, and can obtain obvious effect for curing and preventing senile dementia, preventing and curing Parkinson's disease, curing and preventing ischemic cerebrovascular disease, and have the functions of delaying senility and raising resistance to fatigue and learning memory.

Description

Technical field [0001] The present invention relates to a medicine and health product for treating nervous system diseases, in particular to a medicine and health product containing ganglioside (English name Ganglioside) and Ginkgo biloba extract (English name: ginkgo biloba extract, EGB for short) . Background technique [0002] Ganglioside is a glycosphingolipid containing sialic acid, which is mainly found in the gray matter of mammalian brain. It is a characteristic lipid component of certain neuronal membranes in the central nervous system. Its physical and chemical properties are as follows: [0003] Ganglioside molecules are composed of a hydrophilic group (sialooligosaccharides) and a lipophilic group (ceramides). The lipophilic group is embedded in the double lipid layer of the nerve cell membrane, and the hydrophilic group protrudes from the extracellular fluid, helping to maintain the negative charge on the cell surface to the greatest extent. This physical asymmetry a...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10A61P25/16A61P25/28
Inventor 吴同新潘怡
Owner 上海脑力键生物医学有限公司
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