Antiinflammatory hemostatic gynecologic medicine and use thereof

An anti-inflammatory, hemostatic, and drug technology, which is applied in the field of drugs for the treatment of gynecological diseases, can solve problems such as gastrointestinal discomfort, vomiting, nausea, etc., and achieve the effect of eliminating gastrointestinal discomfort, convenient administration, and small capsule size

Inactive Publication Date: 2003-03-12
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinical practice has also found that due to the fact that there are many ineffective ingredients in the powder, each capsule weighs 280 mg, and the volume is relatively large. After taking it, some patients experience discomfort in the gastrointestinal tract, nausea, and want to vomit.

Method used

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  • Antiinflammatory hemostatic gynecologic medicine and use thereof
  • Antiinflammatory hemostatic gynecologic medicine and use thereof
  • Antiinflammatory hemostatic gynecologic medicine and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 2000 grams of Chonglou, crush it into a coarse powder, add four times the amount of warm water at 55°C and soak it three times, each time for 4 hours. The water solution was discarded; the soaked coarse powder of Chonglou was filtered and dried, and four times the amount of 90% ethanol was added to reflux for extraction three times, each time for 3 hours. Combine the extracts, filter, and at 55°C, recover the ethanol under reduced pressure from the filtrate until the alcohol content is 25%, and the relative density is 1.05, cool and stand for 12 hours, remove the fat in the upper layer of the concentrated solution, and further recover ethanol under reduced pressure, Concentrate to a relative density of 1.15, spray-dry the concentrate, pass through an 80-mesh sieve to obtain dry extract powder, add appropriate amount of auxiliary materials, mix well, and make 1000 capsules to obtain the finished product. The finished product is capsule, and the content is light yell...

Embodiment 2

[0024] In addition to the fact that the filtrate is degreased by recovered ethanol, adsorbed by macroporous adsorption resin, and then eluted with water, 30% ethanol, and ethanol respectively, the ethanol eluted part is collected, the ethanol is recovered, concentrated, dried, crushed, and packaged, which is the finished product. All the other processes are the same as in Example 1.

Embodiment 3

[0026] Because the main components of the raw material are saponins, polysaccharides, and mucus, saponins are further divided into yam saponins and pinanosides. Pharmacological experiments have proved that the active ingredient of Gongxuening is pinnus saponin, which dissolves very little in water, and part of yam saponin can be dissolved. Polysaccharides and mucus are easily soluble in water. According to their properties, water can be used to remove some of them. After the water-soluble substance, the preparation method is extracted with ethanol. Take 1200g of Chonglou coarse powder, divide it into 4 parts, each part is 300g, take three parts, soak them in hot water at 30°C, 60°C, and 90°C respectively, soak three times each time, for 3 hours each time, discard the water soaking solution, Drain. Together with the part that has not been soaked in water, each part is refluxed with ethanol at 90°C for 3 times, each time for 3 hours, the resulting alcohol liquids are combined, ...

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PUM

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Abstract

An anti-inflammatory and staltic medicine for treating gynopathy, especially the chronic pelvic inflammation is prepared from paris polyphylla through crushing, soaking, filtering, extracting, concentrating, drying, pulverizing, etc.

Description

Technical field [0001] The invention relates to a medicine for treating gynecological diseases. Specifically, it relates to the improvement of "Gongxuening Capsule" and the application of the improved Gongxuening Capsule in the pharmaceutical field. Background technique [0002] "Gongxuening Capsule" (trade name) is a gynecological hemostatic drug developed by the applicant in the 1980s. It is a capsule made from the extract of the plant Liliaceae Pachyphyllum yunnanensis or Aescin. At that time, the applicant had applied for an invention patent (CN 85108520A) on the preparation method of Gongxuening Capsules. Gongxuening Capsules, its uterine contraction is one of its hemostatic mechanisms, the mechanism is similar to pituitary hormone and ergot alkaloids. It has the functions of cooling blood to stop bleeding, clearing heat and dehumidification, removing blood stasis and relieving pain. It is used for metrorrhagia, menorrhagia, postpartum or post-abortion uterine contra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P7/04A61P15/00A61P29/00A61P31/02A61P31/04
Inventor 高崇昆赵晓顶张志伟倪凤仪崔占和
Owner YUNNAN BAIYAO GROUP
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