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Sympathetic-activating perfume composition

A sympathetic nerve and composition technology, applied in the directions of hydrocarbon compound active ingredients, heterocyclic compound active ingredients, drug combinations, etc., can solve problems such as unseen

Inactive Publication Date: 2003-03-26
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such spices have various effects on the whole system including psychoactive effects, and are widely used clinically as "aromatherapy" all over the world. However, as for the effects of spices on the autonomic nervous system, they activate the parasympathetic Only a part of the spices of the nervous system is reported, and so far there is no report on the spices that act on the sympathetic nervous system (Japanese Patent Laid-Open 11-209294)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Hereinafter, the present invention will be described in detail through examples, but the present invention is not limited to the following examples. Example 1. Determination of Sympathetic Nerve Activity

[0069] The interval between heartbeats (pulse interval) and fluctuations in blood pressure (blood pressure fluctuation) fluctuate complicatedly even at rest, and are governed by a plurality of systems represented by sympathetic nerves and parasympathetic nerves. Therefore, we know that the activity of each system can be calculated by frequency analysis of beat intervals and blood pressure fluctuations. The high-frequency component of heart rate fluctuations indicates parasympathetic nerve activity, and the low-frequency component indicates mixed activity of the sympathetic and parasympathetic nervous systems. On the other hand, the low-frequency component of blood pressure fluctuations indicates sympathetic nerve activity (Dainippon Pharmaceutical Materials).

[0070...

Embodiment 2

[0077] Comparison of the effects of aroma of essential oils and aroma of hot water extracts on sympathetic nerve activity. As an essential oil is pepper oil. As the hot water extract, black pepper and green pepper hot water extracts prepared by a conventional method were used. As a result, compared with the aroma of the essential oil, it has a high effect, but the aroma of the hot water extract cannot be confirmed to be effective, and it can be found that the aroma components contained in the essential oil greatly contribute to the activation of the sympathetic nerve ( image 3 ). Example 2. Increase in blood catecholamines due to aroma of sympathetic-activating spices

[0078] Among spices that activate sympathetic nerves, pepper oil and pomelo oil were used as examples, and changes in the concentration of catecholamines in blood caused by smelling the aroma of these spices were studied. Let 12 subjects smell the aroma of pepper oil or grapefruit oil respectively, and comp...

Embodiment 3

[0081] Add norepinephrine (0.5ug / ml) to the subcutaneous tissue 70mg of 6-year-old rats, as Figure 6 It was shown that while even caffeine (1 mM) by itself increased deconjugated protein-3 expression, norepinephrine (0.5 ug / ml) and caffeine (1 mM) synergistically increased deconjugated protein-3 expression when added simultaneously. Expression of conjugated protein-3. Example 4. Verification of weight loss effect by continuous use test

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Abstract

Sympathetic nerve-stimulating fragrant compositions with weight-loss effects, characterized by containing one or more selected from among fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olibanum, or one or more from among limonene, pinene, myrcene and benzyl benzoate as the active ingredients in the oils, and preferably also containing caffeine.

Description

field of invention [0001] The present invention relates to perfume compositions for activating sympathetic nerves. More specifically, it relates to a fragrance for activating sympathetic nerves containing at least one or more essential oils. Background technique [0002] The autonomic nervous system is divided into the sympathetic nervous system and the parasympathetic nervous system according to their different functions, which regulate the functions of various organs or organs. Among them, it is known that the activation of the sympathetic nerve involves various actions besides the increase of the heart rate and the inhibition of gastrointestinal peristalsis, and the activation of the sympathetic nerve is also caused by mental stress while receiving the action of hormones and the like. On the other hand, we are familiar with the various spiritual effects of spices from legends, and it has been known for a long time that there are aromas that stabilize emotions, aromas tha...

Claims

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Application Information

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IPC IPC(8): A61K8/37A61K8/49A61K8/92A61K8/97A61K31/01A61K31/015A61K31/216A61K31/522A61K33/00A61K36/185A61K36/235A61K36/282A61K36/324A61K36/53A61K36/532A61K36/537A61K36/54A61K36/61A61K36/67A61K36/752A61K36/9068A61P3/04A61P25/02A61P25/28A61Q13/00A61Q19/06
CPCA61K33/00A61K36/282A61K36/537A61K36/54A61K31/216A61Q19/06A61K36/61A61K36/53A61K8/37A61K8/4953A61K31/015A61K36/235A61K36/185A61K36/324A61K36/67A61K31/01A61K36/9068A61K8/922A61K36/532A61K8/97A61K36/752A61K31/522A61Q13/00A61K8/9789A61P3/04A61P25/02A61P25/28C11B9/00A61K2300/00
Inventor 土師信一郎坂井圭子合津陽子小泉祐貴子針谷毅柴田道男嵜口孝行
Owner SHISEIDO CO LTD
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