4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin

A phenyl and alkyl technology, applied in the direction of medical preparations containing active ingredients, metabolic diseases, preparations for in vivo tests, etc.
CN1413197AInactive Publication Date: 2003-04-23ALBANY MOLECULAR RESEARCH INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ALBANY MOLECULAR RESEARCH INC
Publication Date
2003-04-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided herein are compounds of formulae IA-IF. These compounds are tetrahydroisoquinolines of structure (A) wherein R<1>-R<8> for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein. Said compounds are particularly useful in the treatment of various neurological and psychiatric disorders, e.g., ADHD.
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Description

field of invention

[0001] The present invention relates to compounds, compositions, methods and the use of said compounds in combination therapy for the treatment of various neurological and psychiatric disorders. In particular, the present invention relates to compounds, compositions and methods wherein said compounds are novel 4-phenyl substituted tetrahydroisoquinoline derivatives. Background of the invention

[0002] Serotonin, dopamine and norepinephrine are known to be important chemical messengers involved in the transmission of nerve impulses in the brain. These messengers are released and received at specific sites in the presynaptic cell to complete the transmission of impulses at specific sites in the postsynaptic cell. They are then terminated by metabolism or by uptake into presynaptic cells. Drugs that block the uptake of any of these chemical messengers by presynaptic bodies in the brain would be useful in alleviating diseases associated with reduced levels ...

Claims

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