Sustained release preparation of roxithromycin

A technology of roxithromycin and sustained-release preparations, applied in the field of medicine, can solve the problems of short effective blood drug concentration time, many times of taking, gastrointestinal side effects, etc., to reduce gastrointestinal side effects, improve curative effect, and improve taste sense of effect

Inactive Publication Date: 2003-05-07
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Roxithromycin is a common broad-spectrum anti-inflammatory drug, which has been widely used in the treatment of respiratory infections, genitourinary system infections, skin infections, ENT infections, biliary tract infections and other diseases, but the existing roxithromycin The effective blood concentration time is short, the frequency of taking is more, and it has certain side effects on the gastrointestinal tract

Method used

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  • Sustained release preparation of roxithromycin
  • Sustained release preparation of roxithromycin

Examples

Experimental program
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Effect test

Embodiment 1

[0016] The present embodiment 1 tablet that adopts the known method of pharmaceutical industry to make contains following composition by weight percentage:

[0017] Roxithromycin 50%

[0018] Citric Acid 10%

[0019] HPMCK15M (Methocel K15MCR) 15%

[0020] Lactose 10%

[0021] Microcrystalline Cellulose 6%

[0022] 3% hydroxypropyl methylcellulose ethanol solution (3% HPMC ethanol solution) 3%

[0023] Stearic acid 2%

[0024] Talc 3%

[0025] Magnesium Stearate 1%

[0026] HPMCK15M is a hydrophilic polymer, which is a skeleton material in this preparation, which swells with water or digestive juice to form a gel barrier to control the diffusion of roxithromycin and achieve the purpose of sustained release.

[0027] Among them, HPMCK15M can be replaced by different dosages of HPMCK100LV, HPMCK4M or HPMCK100M, or used in combination to adjust the drug release curve.

Embodiment 2

[0029] The present embodiment 2 tablet that adopts the known method of pharmaceutical industry to make contains following composition by weight percentage:

[0030] Roxithromycin 70%

[0031] Citric Acid 10%

[0032] Carbopol 18%

[0033] Stearic acid 1%

[0034] Talc 1.5%

[0035] Magnesium Stearate 0.5%

[0036] Hydrophilic polymer carboxyvinyl (carbomer) is the skeleton material, which expands to form a gel barrier when it encounters water or digestive juice, and controls the diffusion of roxithromycin to achieve the purpose of sustained release.

Embodiment 3

[0038] The present embodiment 3 tablet that adopts the known method of pharmaceutical industry to make contains following composition by weight percentage:

[0039] Roxithromycin 50%

[0040] Citric Acid 10%

[0041] Sodium Alginate 18%

[0042] Calcium Alginate 3%

[0043] Lactose 11%

[0044] Polyvinylpyrrolidone 6%

[0045] Stearic acid 1%

[0046] Talc 13%

[0047] Magnesium Stearate 0.5%

[0048] The insoluble salt and soluble salt of the hydrophilic polymer alginic acid are used as the skeleton material, which swells with water or digestive juice to form a cross-linked gel barrier to control the diffusion of roxithromycin and achieve the purpose of sustained release.

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Abstract

A showly-releasing roxithromycin contains roxithromycin (30-80 wt.%), slow-releasing assistant (hydroxypropylmethyl cellulose, etc) (10-40 wt.%), and others (hole-forming agent, adhesive, lubricant, etc). Its advantages are long active period (24 hrs.), and low by-effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically, it is a sustained-release preparation of roxithromycin for mainly treating respiratory tract infection, genitourinary system infection, skin infection, otolaryngology infection and biliary tract infection caused by sensitive bacteria. Background technique: [0002] Roxithromycin is a common broad-spectrum anti-inflammatory drug, which has been widely used in the treatment of respiratory infections, genitourinary system infections, skin infections, ENT infections, biliary tract infections and other diseases, but the existing roxithromycin The effective blood concentration time is shorter, the number of times of taking is more, and it has certain side effects on the gastrointestinal tract. Invention content: [0003] The object of the present invention is in order to provide a kind of roxithromycin slow-release preparation that keeps effective blood drug concentration within 24 ho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/7048A61P31/04
Inventor 潘卫三赵雁
Owner SHENYANG PHARMA UNIVERSITY
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