Medicine for relieving spasm and pain and preparation process thereof

A technology of antispasmodic and medicine, which is applied in the field of combination medicine and preparation for headache, and treatment of abdominal smooth muscle spasm pain, and can solve problems such as difficult large-scale preparation

Inactive Publication Date: 2003-10-22
TONGHUA WANTONG PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For this reason, glycyrrhetinic acid can be used as the antispasmodic component in the combination medicine. The above experiments also prove that paeoniflorin and paeoniflorin metabolites are effective ingredients for analgesia and sedation. preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0044] 1. Preparation of glycyrrhetinic acid: Boil the coarse licorice powder with water for 3 times, filter the medicinal solution, add concentrated sulfuric acid until no precipitation occurs, place, filter, brown precipitate, wash with water and dry to obtain crude glycyrrhizic acid. Reflux extraction with acetone for 3 times to obtain acetone extract, let it cool, add 20% KOH ethanol solution to weak alkalinity under stirring, let it stand, and precipitate crystals, filter the crystals (tripotassium glycyrrhizinate), dry, add glacial acetic acid Dissolve in heat, let cool, precipitate crystals, filter to obtain monopotassium glycyrrhizinate, add 5% sulfuric acid, heat for 10 hours, filter with suction, wash with water until neutral, dry to obtain crude white glycyrrhetinic acid, and then dissolve it in hot water In chloroform, filter while it is hot, let the chloroform solution cool, and elute with chloroform on an aluminum peroxide chromatography column to obtain glycyrrhe...

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Abstract

The present invention relates to a medicine for relieving spasm and pain and its preparation method. It utilizes medicine active matter glycyrrhetinic acid extracted from licorice and paenoiflorin extracted from peony root, and uses their respective effective amount and medicinal carrier and/or excpient to make them into the modern medicine with small volume, easy storage, convenient administration and therapeutic effect identical to that of peony licorice decoction. Said medicine also has no toxic effect.

Description

Technical field: [0001] The invention relates to a combination medicine, in particular to a combination medicine for treating abdominal smooth muscle spasms and headaches and a preparation method thereof. Background technique: [0002] Shaoyao Gancao Decoction is a well-known famous prescription in the field of traditional Chinese medicine in China. It is mainly used in the treatment of abdominal smooth muscle spasm and pain such as menstrual pain, uterine cramps and stomach pain. [0003] Although Shaoyao Gancao Decoction has unique curative effects, its dosage form is still a traditional decoction. Obviously, it cannot be produced industrially, but it is boiled by the users themselves. And because the whole material is used as medicine, the active ingredients of the medicine are not clear, and there are no curative or even harmful impurities mixed in it. Therefore, pharmacological analysis of Chinese herbal medicines, isolation of medicinal active substances, and large-s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/191A61K31/353A61K31/79A61K36/484A61K36/65C07D311/30G01N30/02G01N30/90
CPCA61K36/65A61K36/484A61K31/353G01N30/02C07D311/30A61K31/79A61K31/191G01N30/90A61P29/00A61K2300/00
Inventor 王本祥张连珠陈声武李海日
Owner TONGHUA WANTONG PHARMACY
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