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8-(C-beta-D-glycopyranyl)-7,3',4'-trihydroxyflavone, its separating process, medical composition and used for medicine for diabets

A technology of trihydroxyflavone and pyranyl, which is applied in the field of separating the new compound 8--7 and treating diabetes, and can solve the problem of not providing detailed information on biological activity and not publicly preparing the water extract of the heartwood of Indian jina tree methods, methods for isolating chemical components are not disclosed, etc.

Inactive Publication Date: 2003-11-05
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Despite this, however, the prior art does not provide any detailed information on the biological activities associated with such chemical constituents
Moreover, the prior art only discloses the preparation method of the ethyl acetate soluble fraction of the ether extract, ethyl acetate extract and alcoholic extract, but does not disclose the method for preparing the water extract of the Indian Jina heartwood, nor There is no disclosed method for attempting to isolate any chemical constituents therefrom

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Using 80% hydrated ethanol (3×3 liters), the powdery heartwood of the Indian Gina tree was percolated for 48 hours. The obtained concentrate was partitioned sequentially with hexane, chloroform, propanol and butanol. The polar extract was subjected to MPLC treatment using silica gel (100-200 mesh) to obtain a total fraction of sequentially using hexane, chloroform, methanol, and ethanol. The active compound is obtained by using CHCl 3 Purification by repeated MPLC and flash chromatography on silica gel (230-400 mesh) with MeOH (19:1) as solvent afforded 8-(C-β-D-glucopyranyl)-7,3' , 4'-trihydroxyflavone, the yield is 0.046%, mp.202-204℃, [α] D 19 +25.6° (MeOH, c, 0.5).

Embodiment 2

[0047] Using hot water, the heartwood of the Indian Gina tree was extracted for 4×4 hours. The obtained concentrate was partitioned successively between hexane, chloroform, propanol and butanol. The obtained polar extract was subjected to flash chromatography, using hexane, chloroform, ethyl acetate and methanol as solvent system, using silica gel (100-200 mesh) to obtain 8-(C-β- Fraction of D-glucopyranyl)-7,3',4'-trihydroxyflavone, which was then chromatographed repeatedly on silica gel (230-400 mesh) using EtOAc-MeOH (19.5:0.5) as solvent, 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone of structural formula 1 was obtained with a yield of 0.049%, mp.202-204°C, [α] D 19 +25.6° (MeOH, c, 0.5).

Embodiment 3

[0049] The heartwood of the Indian Jina tree was boiled (16 times) with water until 1 / 4 volume of water remained. Filtered, concentrated and partitioned sequentially between hexanes, chloroform, propanol and n-butanol. The resulting polar extract was subjected to column chromatography using hexane, chloroform, ethyl acetate and methanol as the solvent system, using silica gel (60-120 mesh) to obtain a compound rich in 8-(C-β-D -Glucopyranyl)-7,3',4'-trihydroxyflavone fractions. The fraction rich in 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone was continued to use the mixture of ethyl acetate-acetone (8:2) in Repeat column chromatography on silica gel (100-200 mesh) to obtain 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone with a yield of 0.051%, mp. 202-204°C, [α] D 19 +25.6° (MeOH, c, 0.5).

[0050] advantage:

[0051] 1. The obtained compound 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone is a new molecule with antidiabetic activity.

[0052]2. The method for s...

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Abstract

The present invention relates to a new compound 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone, which is isolated from Indian jina tree and can be used for treating diabetes , the present invention also relates to a method for preparing said compound and its use.

Description

field of invention [0001] The present invention relates to a novel compound, 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone. The present invention also relates to a method for isolating said novel compound 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone from Indian gena tree. The present invention also relates to a pharmaceutical composition containing 8-(C-β-D-glucopyranyl)-7,3',4'-trihydroxyflavone and a method for treating diabetes with the compound. Background technique [0002] The Indian Kino tree Roxb (Leguminaceae), also known as Indian Kino tree or Bi jasar, is common in the mountainous regions of central and peninsular India [Jain, S.K., Medicinal Plants, National Book Trust , New Delhi, 1968, p. 116]. The leaves, flowers, and gum of this tree have been used medicinally to treat diarrhea, toothache, fever, urinary tract and skin infections [Chopra, R.N., Chopra, I.C., Handa, K.L. and Kapur, L.D., Indigenous Drugs of India, 2 nd Ed., Dhar, U.N. And Sons Privat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H7/06A61K31/7048A61K36/48A61P3/10C07H17/07
CPCA61P3/10C07H17/07
Inventor 拉凯什·莫里苏克德夫·斯瓦米·汉达拉金德尔·辛格
Owner COUNCIL OF SCI & IND RES
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