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Application of arborane-type triterpenoids against metabolic syndrome and prepared medicine

A technology of triterpenoids and compounds, which is applied in the field of application and prepared medicines, can solve the problems that triterpenoids are rarely found, and achieve the effects of strong pharmacological activity, high safety, and small toxic and side effects

Inactive Publication Date: 2016-11-23
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that triterpenoid saponins have the effect of lowering cholesterol, but triterpenoids that can lower triglycerides are rarely found, especially the application of arborane-type triterpenoids in lipid-lowering drugs has not been reported

Method used

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  • Application of arborane-type triterpenoids against metabolic syndrome and prepared medicine
  • Application of arborane-type triterpenoids against metabolic syndrome and prepared medicine
  • Application of arborane-type triterpenoids against metabolic syndrome and prepared medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Tablet preparation

[0040] Weigh 10 grams of compound 13, 90 grams of hydroxypropyl methylcellulose, 100 grams of polyvinylpyrrolidone, 85 grams of lactose, and 90 grams of micropowdered silica gel, mix compound 13 with the prescribed amount of slow-release agent, and add the binder polyethylene Pyrrolidone is granulated, and the granules are dried at 40-70°C, and the prescribed amount of lubricant micro-powder silica gel is added to the dry granules, mixed evenly, and pressed into tablets.

Embodiment 2

[0042] Preparation of capsules

[0043] Add 300 grams of compound 13, add an appropriate amount of dextrin, mix well, make granules with 85% ethanol, dry, granulate, add micropowder silica gel 5g, mix well, pack into capsules, and make 1000 capsules to obtain capsules of the present invention. Granules 0.35g.

[0044] Three, arborane type triterpenoid drug effect experiment of the present invention

[0045] 1. Olive oil load test in mice

[0046] Experimental method: 60 mice were randomly divided into 6 groups, 10 in each group. Respectively normal group (N), model group (C), orlistat group (PC, 100mg / kg), the sample is compound 13, divided into low dose group (SL, 10mg / kg), sample medium dose group ( SM, 20mg / kg), sample high dose group (SH, 40mg / kg). The mice in each group were fasted for 20-24h before the experiment, and water was deprived for 3-4h before the experiment, and blood was collected from the orbit, as the blood lipid value at 0h. The 0h blood lipid values ​...

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PUM

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Abstract

The invention discloses the application of the arborane-type triterpenoid compound against metabolic syndrome and the prepared medicine, especially the application of the arborane-type triterpene compound in reducing blood fat and blood sugar. The arborane-type triterpenes can significantly inhibit the increase of triglyceride level in olive oil-loaded mice, and inhibit the accumulation of triglyceride in liver cells, so it can be applied to the preparation of lipid-lowering drugs. The arborane-type triterpenoids can be made into any pharmaceutically acceptable preparation. The invention opens up new medical applications of arborane-type triterpenoids, has the characteristics of strong pharmacological effects and high safety, and provides a new effective and safe drug choice for cardiovascular patients.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the anti-metabolic syndrome application of a compound, in particular to the anti-metabolic syndrome application of arborane-type triterpenoids and the prepared medicine. Background technique [0002] With the improvement of people's living standards and changes in lifestyles, diseases that seriously threaten human health and life caused by unhealthy lifestyles and environmental factors are becoming more and more serious. These diseases are collectively referred to as "lifestyle-related diseases", mainly including Hypertension, hyperlipidemia, hyperglycemia and other diseases and obesity. With the changes in people's diet structure and the increase in animal food intake, the number of people suffering from hyperlipidemia and obesity is increasing year by year, and hyperlipidemia is the most risk factor for atherosclerosis and coronary heart disease, and our country dies of heart ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K31/58A61K31/704A61P3/00A61P3/06A61P3/10A23L33/11A23L33/00
Inventor 张海龙高阳王嗣岑
Owner XI AN JIAOTONG UNIV
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