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Preparation method of traditional Chinese medicine extract for regulating glycolipid metabolism

A technology for glucose and lipid metabolism and extracts, which is applied in metabolic diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of unguaranteed effects of lipid regulation and anti-oxidation, and large dosage, and achieve strong anti-diabetic activity, lower blood sugar, The effect of regulating blood lipids

Inactive Publication Date: 2021-04-06
湘潭市中心医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Mulberry leaf-pueraria root is a common medicinal and food homologous drug. It is usually used in large amounts for the treatment of type 2 diabetes. Most of the previous extraction and purification processes used mulberry leaf alkaloids as the main research target, and a large number of flavonoids, flavonoid glycosides, and polyphenols were discarded. Active ingredients, although the hypoglycemic effect is good, but the effects of lipid regulation and anti-oxidation cannot be guaranteed

Method used

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  • Preparation method of traditional Chinese medicine extract for regulating glycolipid metabolism
  • Preparation method of traditional Chinese medicine extract for regulating glycolipid metabolism
  • Preparation method of traditional Chinese medicine extract for regulating glycolipid metabolism

Examples

Experimental program
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Embodiment 1

[0019] A method for preparing a traditional Chinese medicine extract for regulating glucose and lipid metabolism. The steps are as follows: 2 equal parts of mulberry leaves and 1 equal part of kudzu root are pulverized into coarse powder and mixed evenly; Concentrated hydrochloric acid to adjust the pH of the solution to 2.0, heat to 80°C and extract twice, 1 hour each time, filter and combine the filtrate, recover ethanol from the filtrate until it has no alcohol smell, pass through the AB-8 macroporous resin column, and elute with 5BV pure water to remove impurities Finally, 5BV of 50% ethanol (volume concentration) was eluted, and the eluate was collected, concentrated under reduced pressure, and dried.

[0020] The product features are: tan powder, the contents of 1-deoxynojirimycin, quercetin, and puerarin in the powder determined by high performance liquid chromatography are 2-4mg / g, 40-80mg / g, and 150-200mg / g, respectively.

experiment example 1

[0024] Experimental scheme: 24 male SD rats were adaptively raised indoors for 7 days. The rats were randomly divided into a normal group of 6 and a model group of 18. The normal group was given normal feed, and the model group was given high-fat feed. Fasting for 12 hours in the fourth week, the modeling group was intraperitoneally injected with 1% streptozotocin at a dose of 40 mg / kg, and the normal group was given an equal volume of 0.1 mol / L citric acid buffer solution. Three days later, the fasting blood glucose of the rats was measured, and a blood glucose value between 11.1 and 33.3 mmol / L was considered successful in modeling. Rats with successful modeling were randomly divided into 3 groups, 6 in each group, respectively given 0.25 g / kg of mulberry leaves and pueraria root compound extract (medication group) and distilled water, and the normal group was given the same amount of distilled water, once a day, orally administered On the 43rd day, fasting blood glucose a...

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Abstract

The invention belongs to the technical field of extraction and separation of traditional Chinese medicine compound effective components, and particularly relates to a preparation method of a traditional Chinese medicine extract for regulating glycolipid metabolism, which comprises the following steps: mixing mulberry leaf and kudzuvine root powder, adding an ethanol solution, regulating the pH value to 2 or below, heating, leaching, filtering, recovering filtrate, passing through a column, eluting to remove impurities, collecting eluent, concentrating and drying, so that the traditional Chinese medicine extract for regulating glycolipid metabolism is obtained. According to the traditional Chinese medicine extract for regulating glycolipid metabolism, the content of 1-deoxynojirimycin is 2-4mg / g, the content of quercetin is 40-80mg / g, the content of puerarin is 150-200mg / g, and the traditional Chinese medicine extract for regulating glycolipid metabolism has the effects of reducing blood sugar, regulating blood fat, protecting pancreas islet and the like.

Description

technical field [0001] The invention belongs to the technical field of extraction and separation of effective components of traditional Chinese medicine compound, and in particular relates to a preparation method of a traditional Chinese medicine extract for regulating glucose and lipid metabolism. Background technique [0002] Mulberry leaves are the dried leaves of the Moraceae plant mulberry, which has the functions of dispersing wind-heat, clearing lung and moistening dryness, clearing liver and improving eyesight. Pharmacological experiments have shown that active ingredients such as flavonoids and flavonoid glycosides, polyphenols, polysaccharides and alkaloids in mulberry leaves have the effects of lowering blood sugar and improving insulin resistance. Pueraria lobata is the dried root of the leguminous plant Pueraria mirifica, which has the effects of relieving muscle and reducing fever, promoting body fluids and quenching thirst. Pharmacological experiments have sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61P3/10A61P3/06
CPCA61K36/605A61K36/488A61P3/10A61P3/06A61K2236/333A61K2236/53A61K2236/55A61K2236/51A61K2300/00
Inventor 刘湘李伟邢琪昌彭科
Owner 湘潭市中心医院
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