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Dry spaxxacin suspension agent for resisting bacterial infection and its preparing method

A technology of sparfloxacin and dry suspension, which is applied in the field of sparfloxacin dry suspension and its preparation, and can solve problems such as chromosomal abnormalities in lung cells of Chinese mice

Inactive Publication Date: 2003-11-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sparfloxacin has no mutagenic effect on Salmonella strains TA98, TA100, TA1535, TA1537 and Escherichia coli strain WP2, but has a mutagenic effect on Salmonella strain TA102, which can cause Escherichia coli DNA repair; Chromosomal abnormalities in lung cells of Chinese mice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0038] Sparfloxacin 100g

[0039] Micronized silica gel 600g

[0040] Sodium carboxymethyl starch 100g

[0041] Microcrystalline Cellulose 100g

[0042] Polyvinylpyrrolidone 20g

[0043] Cross-linked polyvinylpyrrolidone 20g

[0044] Lactose 50g

[0045] Stevia 10g

[0046] Magnesium Stearate Appropriate amount

[0047] Make 1000 bags

example 2

[0049] Sparfloxacin 100g

[0050] Polyvinylpyrrolidone 120g

[0051] Hydroxypropyl Methyl Cellulose 40g

[0052] Sodium carboxymethyl starch 140g

[0053] Stevia 5g

[0054] Magnesium oxide 10g

[0055] Micronized silica gel 20g

[0056] Flavor 1g

[0057] Mannitol up to 1000g

[0058] Magnesium Stearate Appropriate amount

[0059] Make 1000 bags

example 3

[0061] Sparfloxacin 100g

[0062] Stevia 50g

[0063] Hydroxypropyl Methyl Cellulose 20g

[0064] Micronized silica gel 20g

[0065] Flavor 10g

[0066] Mannitol up to 1000g

[0067] Magnesium Stearate Appropriate amount

[0068] Make 1000 bags

[0069] The preparation method of above-mentioned example sample:

[0070] Take sparfloxacin and auxiliary materials, dry and pulverize them and pass through an 80-mesh sieve, and use the equal-increasing method to mix the active ingredients with fillers, adsorbents, glidants, suspending agents and / or suspending agents, flavoring agents, surface The active agent and the lubricant are fully mixed and evenly distributed, and ready to be prepared.

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PUM

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Abstract

The present invention relates to a kind o dry Sparxacin suspension agent for resisting bacterial infection and its preparation process. The dry Sparxacin suspension agent is prepared with Sparxacin as active component and through adding stuffing, adsorbent, flow assistant, suspending agent, corrective, surfactant and lubricant. It has high Sparxacin digesting rate and is favorable to taking by old patient and patient with dysphagia.

Description

technical field [0001] The invention relates to a preparation of antibacterial drugs and a preparation method thereof, in particular to sparfloxacin dry suspension and a preparation method thereof. technical background [0002] Sparfloxacin (Sparfloxacin) is a fluoroquinolone antibacterial drug developed by Japan Dainippon Pharmaceutical Co., Ltd. It introduces an amino group at the 5-position of the oxidized quinoline skeleton of the mother nucleus, which makes the drug more effective than other fluoroquinolone antibacterial drugs. The antibacterial activity of Gram-positive bacteria is enhanced, fluorine is added to the 6-position and 8-position, and there is 3,5-dimethylpiperazinyl at the 7-position, which weakens the drug's resistance to fenbufen, theophylline, and probenecid. Interaction. After the above structural changes, its bioavailability is improved, its half-life is prolonged, and its antibacterial activity against Gram-positive bacteria and negative bacteria is...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/496A61P31/04
Inventor 刘智钱进许军彭红刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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