Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of Bacille Calmette-Guerin polysaccharide nucleic acid in the preparation of medicine for oral cavity local administration

A BCG polysaccharide nucleic acid and local administration technology, which is applied in the directions of drug combinations, anti-infectives, pharmaceutical formulations, etc., can solve the problems of difficulty in directly acting on the lesion site, inability to satisfy local administration, and inconvenient administration. To achieve the effect of enhancing the total number of T cells, less toxicity, and convenient medication

Inactive Publication Date: 2004-02-18
CHENGDU INST OF BIOLOGICAL PROD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional method of applying BCG polysaccharide nucleic acid clinically is intramuscular injection. Although the curative effect of the injection route is affirmative, it has the following disadvantages: one is that the clinical injection route is inconvenient to use, and the other is that BCG Bacterial polysaccharide nucleic acid has a long course of clinical treatment, if the patient gives up the treatment halfway, it will delay the condition
BCG polysaccharide nucleic acid injection is used to treat chronic bronchitis, colds, and asthma. It is difficult to achieve the purpose of directly acting on the lesion site by intramuscular injection, and it cannot satisfy local administration.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2   preparation a and b Embodiment 1，c、、 3 ：HPC/CP，，，，2mg。 Embodiment 3

[0019] Through the above-mentioned method, each tablet can be prepared to contain 6 mg and 2 mg of BCG polysaccharide nucleic acid. Example 2 The preparation steps a and b of the BCG polysaccharide nucleic acid adhesive sheet are the same as in Example 1, c, and the auxiliary materials and BCG polysaccharide nucleic acid are divided into three layers: the lower layer uses HPC / CP as the matrix, and the middle layer is the BCG polysaccharide nucleic acid , the upper layer is lactose, directly compressed, each tablet contains 2mg of BCG polysaccharide nucleic acid. Example 3 BCG polysaccharide nucleic acid film preparation steps a and b are the same as in Example 1, c, use polyethylene as the substrate, and use a film press to directly compress the film-forming agent, each tablet containing BCG polysaccharide nucleic acid 6mg. Embodiment 4 BCG polysaccharide nucleic acid spray steps a and b are the same as in Example 1, c, mix with BCG polysaccharide nucleic acid with conventiona...

experiment example 4

[0049] Through analysis of variance, the result prompts that high, medium and low doses of the medicine of the present invention can significantly increase the half hemolysis value HC of mice. 50 (p<0.001), and there is no significant difference between the results of high and middle dose groups and the positive control group (BCG polysaccharide nucleic acid intramuscular injection group and PHA control group), indicating that it has the same curative effect as intramuscular injection of BCG polysaccharide nucleic acid. Experimental example four Drug desensitization experiment of the present invention 1, experimental material:

[0050] Reagent: drug of the present invention: BCG polysaccharide nucleic acid buccal tablet prepared in Example 1; BCG polysaccharide nucleic acid intramuscular injection (Kashuning injection), provided by Chengdu Institute of Biological Products, batch number 20020206.

[0051] Animals: 60 guinea pigs, half male and half male, weighing 250-300 g, pro...

test approach 21

[0090] 1.2 Select 25±2g healthy Kunming mice, 16 mice in each experimental group, half male and half male. 2. Test method 2.1 Dosage: The test group BCG polysaccharide nucleic acid took 3 doses, respectively: BCG polysaccharide nucleic acid 1mg + excipient 9mg / piece, BCG polysaccharide nucleic acid 2mg+excipient 8mg / piece, card 4 mg of polysaccharide nucleic acid of the bacteria + 6 mg of excipients per mouse; the control group received 10 mg of excipients per mouth. 2.2 Grouping and observation: The mice were randomly divided into 8 groups according to gender, including 4 female groups and 4 male groups; the three experimental groups were administered to the mice at the above dose, and the control group was only given the same amount of excipients, and the mice were given The animal death situation was observed for 10 consecutive days afterward, and each group was weighed after 10 days. 3. Experimental results

[0091] 3.1 The results of observation and weighing of mice aft...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
weightaaaaaaaaaa
Login to View More

Abstract

An application of Calmette-Gurin bacillus' polyose and nucleic acid in preparing the medicines for treating chronic bronchitis, cold and asthma by applying it to local position of oral cavity is disclosed. Its advantages are high curative effect, low poison and by-effect, and high safety.

Description

technical field [0001] The present invention relates to the use of BCG polysaccharide nucleic acid, specifically, the use of BCG polysaccharide nucleic acid in the preparation of medicines for local oral administration. Background technique [0002] Chronic bronchitis, asthma, allergic rhinitis, and allergic skin diseases are all common and frequently occurring diseases in spring. Clinically, there are many antibacterial, antihistamine, and hormonal drugs. It is not a difficult problem to control the symptoms of these diseases when they attack, but they cannot control their repeated attacks. The application and promotion of BCG polysaccharide nucleic acid has added an effective method to control the recurrence of these diseases. However, the traditional method of applying BCG polysaccharide nucleic acid clinically is intramuscular injection. Although the curative effect of the injection route is affirmative, it has the following disadvantages: one is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/70A61K31/715A61P11/00A61P11/06A61P31/00
Inventor 晏子厚屈戈周如娇何菊曹慧徐永革吴先勇杨永芳
Owner CHENGDU INST OF BIOLOGICAL PROD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com