Medicine composition with two-way immune regulation function by oral cavity local administration

A technology of local drug delivery and two-way immunization, used in drug combinations, anti-infective drugs, pharmaceutical formulations, etc., can solve problems such as difficulty in directly acting on the lesion, inability to meet local drug delivery, and inconvenience in drug use, and achieve enhanced T The effect of total number of cells, low toxicity and convenient administration

Inactive Publication Date: 2005-12-21
CHENGDU INST OF BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional method of applying BCG polysaccharide nucleic acid clinically is intramuscular injection. Although the curative effect of the injection route is affirmative, it has the following disadvantages: one is that the clinical injection route is inconvenient to use, and the other is that BCG Bacterial polysaccharide nucleic acid has a long course of clinical treatment, if the patient gives up the treatment halfway, it will delay the condition
BCG polysaccharide nucleic acid injection is used to treat chronic bronchitis, colds, and asthma. It is difficult to achieve the purpose of directly acting on the lesion site by intramuscular injection, and it cannot satisfy local administration.

Method used

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  • Medicine composition with two-way immune regulation function by oral cavity local administration
  • Medicine composition with two-way immune regulation function by oral cavity local administration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Preparation of BCG polysaccharide nucleic acid buccal tablet

[0018] a. The preparation of BCG cells by liquid floating film culture technology and solid culture technology involves the preparation of specific Soton's medium (1000ml)

[0019] MgSO 4 0.5g

[0020] K 2 HPO 4 0.5g

[0021] Citric acid 2g

[0022] MSG 8g

[0023] Glycerin 60ml

[0024] Ferric Ammonium Citrate 0.05g

[0025] 1‰zinc sulfate 1ml

[0026] Method: heat water to dissolve, adjust pH to 7.5 with ammonia water, sterilize at 0.1Mpa for 30 minutes. BCG cell culture technology

[0027] Inoculate the BCG strains stored in Sutong’s potato medium to the above-mentioned specific Sutong’s medium, and cultivate them at 38±0.5°C for 7 days to become S 1 Bacteria, the S 1 Bacterial film inoculated in Sutong's medium and cultured continuously for 10-12 days is S II Bacteria, with S II The bacterial film was then inoculated with the a...

Embodiment 2

[0033] Example 2 Preparation of BCG polysaccharide nucleic acid adhesive sheet

[0034] Steps a and b are the same as in Example 1, c, and the auxiliary materials and BCG polysaccharide nucleic acid are divided into three layers: the lower layer uses HPC / CP as a substrate, the middle layer is BCG polysaccharide nucleic acid, and the upper layer is lactose, which is directly compressed into tablets, and each tablet contains BCG polysaccharide nucleic acid 2mg.

Embodiment 3

[0035] Example 3 Preparation of BCG polysaccharide nucleic acid film

[0036] Steps a and b are the same as in Example 1, c, using polyethylene as the substrate, and directly compressing the film-forming agent with a film press, each containing 6 mg of BCG polysaccharide nucleic acid.

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Abstract

The invention relates to a new application of BCG polysaccharide nucleic acid in the preparation of medicine for local administration in the oral cavity, which can achieve two-way immune regulation through the local administration in the oral cavity, so as to treat chronic bronchitis, cold and asthma. The present invention also provides an effective amount of BCG polysaccharide nucleic acid plus pharmaceutically acceptable auxiliary materials to prepare a pharmaceutical composition with two-way immunoregulatory function for local administration in the oral cavity. The composition has the ability to treat chronic bronchitis, cold, asthma and other functions. The local oral administration using the BCG polysaccharide nucleic acid has the advantages of good curative effect, low toxicity, few side effects, high safety, and convenient administration.

Description

technical field [0001] The invention relates to a pharmaceutical composition with two-way immunoregulatory function for local administration in the oral cavity, specifically, a pharmaceutical composition for local administration in the oral cavity with BCG polysaccharide nucleic acid as the active ingredient. Background technique [0002] Chronic bronchitis, asthma, allergic rhinitis, and allergic skin diseases are all common and frequently occurring diseases in spring. Clinically, there are many antibacterial, antihistamine, and hormonal drugs. It is not a difficult problem to control the symptoms of these diseases when they attack, but they cannot control their repeated attacks. The application and promotion of BCG polysaccharide nucleic acid has added an effective method to control the recurrence of these diseases. However, the traditional method of applying BCG polysaccharide nucleic acid clinically is intramuscular injection. Although the curativ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K9/70A61K31/715A61P11/00A61P11/06A61P31/00
Inventor 晏子厚屈戈周如娇何菊曹慧徐永革吴先勇杨永芳
Owner CHENGDU INST OF BIOLOGICAL PROD
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