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Java brucea oil-emulsion injecta with low-toxicity and preparing method thereof

The technology of bruce japonica oil and bruce japonica is applied in the directions of emulsion delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc. Stable quality, uniform milk grains, inhibiting biosynthesis

Inactive Publication Date: 2004-04-14
李宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problems of high toxicity, poor safety and many adverse reactions of Brucea javanica oil emulsion injection, we conducted a series of studies and found that the water-soluble components in Brucea javanica are highly toxic, although the original process selectively extracted Brucea javanica oil, most of the water-soluble toxic components are removed, but the obtained Brucea javanica oil still contains a small amount of water-soluble components

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Recipe: refined Brucea javanica oil 100ml

[0024] Refined soybean lecithin 15g

[0025] Glycerin 25ml

[0026] Add water for injection to 1000ml

[0027] Preparation method: First, pour the refined Brucea javanica oil into a mixing tank and heat to 80°C, then add soybean lecithin, shear and mix evenly.

[0028] Add the water for injection into the circulating tank of the high-pressure homogenizer, add glycerin, heat to 75°C to mix, turn on the homogenizer, and slowly add the sheared and mixed mixture of refined brucea javanica oil and soybean lecithin from the oiling hole. After the addition is complete, close the refueling hole, adjust the pressure of the high-pressure homogenizer, make the low pressure 10MPa, high pressure 32Mpa, continuous cycle 5 times, sample inspection, potting and sterilization.

Embodiment 2

[0029] Example 2 Recipe: refined Brucea javanica oil 100ml

[0030] Refined soybean lecithin 10g

[0031] Glycerin 10ml

[0032] Add water for injection to 1000ml

[0033] Preparation method: First, pour the refined Brucea javanica oil into a mixing tank and heat to 60°C, then add soybean lecithin, shear and mix evenly.

[0034] Add the water for injection into the circulating tank of the high-pressure homogenizer, add glycerin, heat to 75°C to mix, turn on the homogenizer, and slowly add the sheared and mixed mixture of refined brucea javanica oil and soybean lecithin from the oiling hole. After the addition is complete, close the refueling hole, adjust the pressure of the high-pressure homogenizer, make the low pressure 30MPa, the high pressure 50Mpa, continuously cycle 5 times, sample for inspection, potting and sterilization. .

Embodiment 3

[0035] Example 3 Recipe: refined Brucea javanica oil 100ml

[0036] Refined soybean lecithin 100g

[0037] Glycerin 100ml

[0038] Add water for injection to 1000ml

[0039] Preparation method: First, pour the refined Brucea javanica oil into a mixing tank and heat to 80°C, then add soybean lecithin, shear and mix evenly.

[0040] Add the water for injection into the circulating tank of the high-pressure homogenizer, add glycerin, heat to 75°C to mix, turn on the homogenizer, and slowly add the sheared and mixed mixture of refined brucea javanica oil and soybean lecithin from the oiling hole. After the addition is complete, close the refueling hole, adjust the pressure of the high-pressure homogenizer, make the low pressure 10MPa, high pressure 32Mpa, continuous cycle 5 times, sample inspection, potting and sterilization.

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Abstract

The invention discloses a low-toxicity Java Brucea Fruit oil milk injection liquid and preparing method. Take Java brucea Fruit oil or refined Java brucea fruit oil to heat, and add in bean lipoid to mix; take injection water and glycerin to mix, heat to 75íµ, slowly add in the mixture of Java Brucea Fruit oil and bean lipoid, use high-pressure homogenizer to circularly emulsify for 3-6 times, sample, assay, seal by pot and sterilize to make it. Heat Java brucea fruit oil to 80-100íµ, slowly inject in tepid injection water, heat and mix, place still to delaminate, and eliminate the water layer to make the refined Java brucea fruit oil.

Description

Technical field [0001] The invention relates to a low-toxic Brucea javanica oil emulsion injection and a preparation method thereof Background of the invention [0002] Brucea javanica oil emulsion injection is mainly used clinically to treat lung cancer and gastrointestinal tumors, and the main active ingredient is oleic acid. Since the 1970s, domestic experts have noticed the anti-cancer effect of the traditional Chinese medicine Brucea javanica, and have carried out pharmacological, pharmacological and clinical studies. They have been used in the treatment of lung cancer, lung cancer brain metastases, gastrointestinal tumors, and cancerous pleural and ascites Good curative effect, but there are many problems in product safety, and there are many adverse reactions. Public reports show that the main adverse reactions of Brucea javanica oil emulsion injection are: nausea, anorexia, vomiting, rapid heart rhythm and breathing, and cyanosis , Severe cases can lead to arrhythmia and ...

Claims

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Application Information

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IPC IPC(8): A61K9/113A61P35/00
Inventor 李宏朱德领于自勋
Owner 李宏
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