Methanesul fonic pazuthacin injection and its preparing process against infection

A preparation technology of pazufloxacin mesylate, applied in antibacterial drugs, pharmaceutical formulations, drug delivery, etc., can solve problems such as long-term toxicity and reproductive toxicity, and achieve stable and controllable quality

Inactive Publication Date: 2004-04-21
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0086] 3. Toxicology
[0089] (2) Long-term toxicity
[0092] (3) Reproductive toxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 2

[0243] prescription:

[0244] Pazufloxacin mesylate 65.1g (calculated as 50g by Pazufloxacin)

[0245] Methanesulfonic acid 20mg

[0246] Add water for injection to 1000ml, pack into 100 vials, 10ml / vial, 500mg / vial

example 3

[0248] prescription:

[0249] Pazufloxacin mesylate 32.55g (25g as Pazufloxacin)

[0250] Methanesulfonic acid 30mg

[0251] Add water for injection to 1000ml, pack into 50 tubes, 20ml / bottle, 500mg / bottle

[0252] 4. Example 4

[0253] prescription:

[0254] Pazufloxacin mesilate 130.2g (calculated as 100g by Pazufloxacin)

[0255] Methanesulfonic acid 20mg

[0256] Add water for injection to 1000ml, pack into 1000 vials, 1ml / vial, 100mg / vial

[0257] 5. Example 5

[0258] prescription:

[0259] Pazufloxacin mesylate 65.1g (calculated as 50g by Pazufloxacin)

[0260] Methanesulfonic acid 20mg

[0261] Add water for injection to 1000ml, pack into 500 vials, 2ml / vial, 100mg / vial The sample preparation process of the above example

[0262] (1) Ingredients: Take the prescribed amount of pazufloxacin mesylate and methanesulfonic acid, add water for injection (around 40°C) to the full amount, stir to dissolve, add activated carbon, and stir for 15 minutes. The sand c...

example 7

[0272] prescription:

[0273] Pazufloxacin mesylate 3.906g (calculated as 3g by Pazufloxacin)

[0274] Glucose 50g

[0275] Methanesulfonic acid 27mg

[0276] Add water for injection to 1000ml, divide into 10 bottles, 100ml / bottle, 300mg / bottle

[0277] 8. Example 8

[0278] prescription:

[0279] Pazufloxacin mesylate 3.906g (calculated as 3g by Pazufloxacin)

[0280] Glucose 50g

[0281]Sodium chloride 9g

[0282] Methanesulfonic acid 30mg

[0283] Add water for injection to 1000ml, divide into 10 bottles, 100ml / bottle, 300mg / bottle

[0284] 9. Example 9

[0285] prescription:

[0286] Pazufloxacin mesylate 6.51g (calculated as 5g by Pazufloxacin)

[0287] Sodium chloride 9g

[0288] Methanesulfonic acid 50mg

[0289] Add water for injection to 1000ml, pack into 10 bottles, 100ml / bottle, 500mg / bottle

[0290] 10. Example 10

[0291] prescription:

[0292] Pazufloxacin mesylate 6.51g (calculated as 5g by Pazufloxacin)

[0293] Glucose 50g

[0294] Methanesul...

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PUM

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Abstract

A Pazhushaxing methanesulphonate injection including its freeze dried one is prepared from the Pazhushaxing methanesulphonate, water for injection and additive.

Description

technical field [0001] The present invention relates to a kind of quinolone antibiotic injection and preparation technology thereof, specifically, a kind of chemical name is (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methanol Base-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid methanesulfonate, the structural formula is: Molecular formula is C 16 h 15 FN 2 o 4 ·CH 4 SO 3 , a sterilized solution made of pazufloxacin mesylate with a molecular weight of 414.41 for injection into the body, and a sterile powder or concentrated solution for making a solution before use. technical background [0002] Quinolones are a relatively new class of synthetic antibacterial drugs. They are different from other antibacterial drugs. They target bacterial DNA and prevent bacterial DNA from forming supercoils by preventing DNA topoisomerase II and IV from functioning. , further causing irreversible damage to chromosomes, resulting in the inability of bacterial ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/5365A61P31/04
Inventor 刘孝乐刘智钱进许军彭红朱丹
Owner HONGYI SCI & TECH CO LTD NANCHANG
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