Silymarin behenic acid glyceride lipid nano particle oral solution dosage and its preparation method

A technology of glyceryl behenic acid lipid and glyceryl behenic acid, which is applied in the field of silymarin glyceryl behenic acid lipid nanoparticle oral solution and its preparation, can solve the problems of complex active ingredients of traditional Chinese medicine, and improve bioavailability degree, good curative effect

Inactive Publication Date: 2004-05-05
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of the active ingredients of traditional Chinese medicine,

Method used

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  • Silymarin behenic acid glyceride lipid nano particle oral solution dosage and its preparation method
  • Silymarin behenic acid glyceride lipid nano particle oral solution dosage and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Weigh 0.120g of silymarin, 2.0g of behenic acid glyceride, and 1.5g of soybean lecithin, and heat it in a water bath at 85°C to dissolve it in 15ml of absolute ethanol, continue heating, and after wiping off the organic solvent, quickly Freeze at 0°C for 2 hours and set aside;

[0027] (2) Take 1.5g of poloxamer188 and 2.5g of glycerol and disperse them in 100ml of water at 4°C to form a uniform water phase for later use;

[0028] (3) Mix and grind (mortar, homogenizer) the solid obtained from (1) and the water phase obtained from (2) at 4°C until the particle size is below 100 μm (through a 180-mesh sieve) to form uniform particles water dispersion system.

[0029] (4) The water dispersion obtained in (3) is circulated 5 times (3 minutes) at room temperature and a pressure of 700 bar (Niro Soavi high-pressure homogenizer) for high-pressure homogenization, and the water dispersion is cooled to 10° C. with an ice bath, and then Circulate rapidly for 5 times (3 minu...

Embodiment 2

[0031] The same method as in Example 1 was used, wherein the amount of silymarin added was 1.0 g / 100 ml, glyceryl behenate was 40 g / 100 ml, soybean lecithin was 10 g / 100 ml, poloxamer188 was 10 g / 100 ml, and glycerin was 39.5 g / 100 ml.

Embodiment 3

[0033] The same method as in Example 1 was used, wherein the amount of silymarin added was 0.05g / 100ml, glycerol behenate was 20mg / 100ml, soybean lecithin was 15mg / 100ml, poloxamer188 was 10mg / 100ml, and glycerin was 39.5mg / 100ml.

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Abstract

An oralloy applied solution of silymarinum-glyceride behenate nanoparticles is prepared from silymarinum, glyceride behenate and soybean phosphatide as carrier, and poloxamer 188 and glycerine as suspending aid by solvent-fusing dispersion method and high-pressure emulsifying and homogenizing method. Its advantages are high biologic utilization rate and higher curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine behenic acid glyceride lipid nanoparticle oral solution and a preparation method thereof, in particular to a silymarin behenic acid glyceride lipid nanoparticle oral solution and a preparation method thereof. Background technique [0002] Silymarin is an active ingredient extracted from milk thistle of Compositae, which is mainly used to treat liver fibrosis, acute and chronic hepatitis and other liver diseases. [0003] Silymarin is an insoluble fat-soluble drug, and the absorption and bioavailability of conventional dosage forms are not ideal, which cannot meet the needs of clinical medication. [0004] Traditional microparticle drug delivery systems mainly include emulsions, liposomes, microspheres, etc., and the materials used in their preparation are mostly synthetic polymers or some polymer materials. In the 1970s, nanotechnology began to be applied to pharmacy, and a nano drug delivery sys...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K9/14A61K31/357A61P1/16A61P31/12
Inventor 奉建芳陆伟根何军
Owner SHANGHAI INST OF PHARMA IND
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