Method for treating inflammation of muscular skeleton and connective tissue

Abstract

A method of treating said musculoskeletal and connective tissue inflammations including osteoarthritis and associated articular and periarticular inflammations, and non-articular Rheumatism including capsulitis, tendonitis, fibrositis, and perarticular inflammations is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a patient of an initial dosage of a composition comprising 13-cis-retinoic acid for an initial treatment period, and thereafter administering a maintenance dosage of the composition.

Description

technical field

[0001] The present invention relates to a method of treating musculoskeletal and connective tissue inflammation. More specifically, the present method employs 13-cis retinoic acid to effectively treat musculoskeletal and connective tissue inflammation including osteoarthritis and joint and periarticular inflammation associated with osteoarthritis, and non-articular rheumatic diseases, which include bursitis, tendonitis, fibrositis, and periarticular inflammation. Background technique

[0002] Musculoskeletal and connective tissue inflammation is a common disease affecting large numbers of people. Some common musculoskeletal and connective tissue inflammations include osteoarthritis and joint and periarticular inflammation associated with osteoarthritis, and non-articular rheumatic diseases, which include bursitis, tendonitis, fibrosis, and joint Peripheral inflammation.

[0003] Osteoarthritis is one of the most common types of arthritis, more common in th...