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Total sanchinoside and ferulic acid composition for treating cardio-cerebral vascular disease and diabetes and its use

A technology of Panax notoginseng saponins and cardiovascular and cerebrovascular diseases, which is applied in cardiovascular system diseases, drug combinations, metabolic diseases, etc. It can solve the problems of comprehensive curative effect to be improved, unclear formula relationship, difficult quality control, etc., and achieve easy quality control , comprehensive curative effect is good, the effect of improving activity

Inactive Publication Date: 2004-07-14
YUNNAN WUXIN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Panax notoginseng saponins and ferulic acid have certain curative effects on cardiovascular and cerebrovascular diseases and diabetic complications, their comprehensive curative effect needs to be improved
Although traditional medicine has some compound prescriptions (such as compound salvia miltiorrhiza, etc.) for the prevention and treatment of cardiovascular and cerebrovascular diseases and diabetes, their components are complex, the relationship between the formulas is unclear, the prescriptions are not refined, and the quality is difficult to control.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Compound Notoginseng Total Saponins and Ferulic Acid Jiangxuezhi Granules

[0041] formula:

[0042] Panax notoginseng saponins 95g

[0043] Ferulic Acid 5g

[0044] Sucrose 3000g

[0045] Dextrin 400g

[0046] Proper amount of ethanol

[0047] Granulate according to the common granulation method, and pack into 1000 bags (about 3.5g per bag). Take one bag each time, 1-2 times a day.

Embodiment 2

[0048] Example 2: Compound Panax notoginseng saponins and ferulic acid capsules

[0049] formula:

[0050] Panax notoginseng saponins 75g

[0051] Ferulic Acid 25g

[0052] Polyethylene-400 300g

[0053] According to the preparation method of ordinary capsules, the content of each capsule weighs about 400mg, and 1000 capsules can be obtained.

[0054] 35 patients with myocardial infarction were treated with this product. After 28 days of treatment, more than 95% of the patients were relieved to varying degrees, of which 44.2% were markedly effective and 52.8% were improved. The total effective rate of electrocardiogram is 66.4%.

Embodiment 3

[0055] Example 3: Compound Panax notoginseng saponins and ferulic acid freeze-dried powder injection

[0056] formula:

[0057] Panax notoginseng saponins 125g

[0058] Ferulic Acid 75g

[0059] Mannitol 100g

[0060] Prepare the freeze-dried preparation according to the ordinary freeze-drying method, and can obtain 1,000 tubes of 200 mg of compound notoginseng total saponins and ferulic acid freeze-dried powder injection.

[0061] Pharmacodynamic Test of Compound Panax notoginseng Total Saponins and Ferulic Acid Powder Injection

[0062] Equal volume of normal saline (NS), compound Danshen injection and compound notoginseng saponins and ferulic acid powder injection were used as the negative control group, positive control group and experimental group respectively, and compound notoginseng total saponins and ferulic acid powder injection antagonized The reduction of coronary artery flow in the isolated guinea pig heart induced by vasopressin (p<0.01) has a dose-effect relat...

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PUM

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Abstract

The present invention relates to a kind of composition for treating cardiac and cerebral vascular diseases and diabetes and its application. The present invention aims at raising the comprehensive curative effect of total sanchinoside and ferulic acid in treating cardiac and cerebral vascular diseases and diabetes. The composition of the present invention consists of total sanchinoside in 5-95 wt% and ferulic acid 5-95 wt%. By means of the synergistic effect of total sanchinoside and ferulic acid, the composition can regulate blood function, treat diseases caused by blood system, cardiac and cerebral vascular change and blood sugar change and improve function. The composition may be prepared into medicinal acceptable preparation via adding proper amount of medicinal supplementary material and has high comprehensive curative effect.

Description

Technical field: [0001] The invention relates to a composition for preventing and treating cardiovascular and cerebrovascular diseases and diabetes, in particular to a biologically active composition composed of Panax notoginseng saponins and ferulic acid, and the composition is used in the preparation of medicines and foods the use of. Background technique: [0002] Panax notoginseng (also known as Panax notoginseng, Tianqi, southern ginseng) is a plant of the genus Panax of Araliaceae. Its roots, leaves, flowers, etc. have medicinal value, and mainly contain ginsenosides and other substances. Research data proves that Panax notoginseng saponins extracted from Panax notoginseng can effectively improve the hemodynamics of blood circulation, reduce blood viscosity, lower blood lipids, and improve beauty. It is a commonly used natural extract and has national standards. Ferulic acid is one of the main components of Angelica and Chuanxiong. Ferulic acid has the functions of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P3/10A61P9/10
Inventor 余树华
Owner YUNNAN WUXIN IND
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